Krushnakant Wagh*

M.V.Sc Scholar (Department of Veterinary Epidemiology and Preventive Medicine), College of Veterinary and Animal Sciences, Pabhani and Maharashtra Animal and Fishery Sciences University, Nagpur, (Maharashtra), India

*Corresponding Author: Krushnakant Wagh, M.V.Sc Scholar (Department of Veterinary Epidemiology and Preventive Medicine), College of Veterinary and Animal Sciences, Pabhani and Maharashtra Animal and Fishery Sciences University, Nagpur, (Maharashtra), India.

Received: February 22, 2024Published: March 08, 2024

Abstract

The recklessness with which important yet menacing (if not used cautiously) drugs being used in veterinary medicine creating more harm than benefit. Be it Nsaid’s, the overdosage of which causes acute kidney failure or be it ivermectin which if given in quantity more than recommended will result in multiple harmful signs such as tremors, incoordination, ataxia, transient blindness etc. Similarly, here the case of dog was presented at VCC, COVAS, Parbhani. The history of administration of ivermectin, more than 3 times of ideal dosage and the corresponding signs exhibited by dog were self-evident of the toxicity. The haematological and biochemical parameters were ideal and no abnormality was observed in them. As a result, after taking into account all the differentials and history taking, the present case diagnosed as case of ivermectin toxicity. Since there’s dearth of antidote against ivermectin, supportive and symptomatic treatment was carried out. The dog was administered with anticholinesterase medication (neostigmine), acetylcholinergic antagonist (atropine sulphate), neuroprotectants and intravenous dextrose infusions twice in period of 12 hrs. Animal showed signs of recovery within 2 hrs of end of first treatment, however it took 2 days for complete recovery of dog.

Keywords: Ivermectin; Neostigmine; Atropine Sulphate; Sialorrhea

References

1. Bhikane AU., et al. “Successful therapeutic management of Ivermectin toxicity in Deoni calf”. Journal of Dairy and Veterinary Sciences 4 (2017): 555594.
2. Dias B L S., et al. “Treatment of drooling with sublingual atropine sulfate in children and adolescents with cerebral palsy”. Arquivos De Neuro-psiquiatria5 (2017): 282-287.
3. Duce and Scott. “Actions of dihydroavermectin B1a on insect muscle”. British Journal of Pharmacology 85 (1985): 395-401.
4. Geary T G., et al. “Haemonchus contortus: ivermectin induced paralysis of the pharynx”. Experimental Parasitology 77 (1993): 88-96.
5. Goldstein and Betz. “The blood-brain barrier”. Scientific American 255 (1986): 74-83.
6. Gupta and Qureshi. “Potential Benefits of Methylcobalamin: A Review”. Austin Journal of Pharmacology and Therapeutics 3 (2015): 1076.
7. Muhammad G., et al. “Use of neostigmine in massive ivermectin toxicity in cats”. Veterinary and Human Toxicology 1 (2004): 28-29.
8. Neely GA., et al. “Neostigmine”. In: StatPearls. Treasure Island (FL): StatPearls (2024).
9. Omura and Crump A. “The life and times of ivermectin - a success story”. Nature Reviews Microbiology12 (2004): 984-989.
10. Pulliam J D., et al. “Investigating ivermectin toxicity in Collies”. Veterinary Medicine 80 (1985): 33-40.
11. Schinkel A H., et al. “Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs”. Cell 77 (1994): 491-502.
12. Sheikh Tajamul Islam., et al. “Ivermectin Toxicity in a German Shepherd Cross Breed Dog: A Case Study”. International Journal of Current Microbiology and Applied Sciences 11 (2017): 1452-1455.
13. Tatsuta T., et al. “Functional involvement of P-glycoprotein in blood-brain barrier”. Journal of Biological Chemistry 267 (1992): 20383-20391.

Citation

Citation: Krushnakant Wagh. “Clinical Management of Ivermectin Toxicity in Dog".Acta Scientific Veterinary Sciences 6.4 (2024): 16-19.

Copyright

Copyright: © 2024 Krushnakant Wagh. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.