Wilson O Ajawanchukwu¹, Nosa T Omorodion²* and Godfrey I Iyare¹

¹Department of Medical Laboratory Science, Faculty of Applied Health Sciences, Benson Idahosa University, Benin city, Edo State, Nigeria
²Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Edo State, Nigeria

*Corresponding Author: Nosa T Omorodion, Department of Medical Laboratory Science, School of Basic Medical Sciences, College of Medical Sciences, University of Benin, Edo State, Nigeria.

Received: January 16, 2024Published: February 15, 2024

Abstract

There have been reports of the protective and healing properties of coconut water in almost every bodily system and in a number of disease states, including those involving the heart and lung systems. The study is aimed at assessing the therapeutic potential of Cocos nucifera (coconut) on selected narcotics that induce toxicity in the lungs and hearts of albino rats. In this study, 50 rats were used; the rats were weighed before receiving the substances (Tramadol, Codeine, and Rohypnol) and were thus divided into five groups. Group A (Control) received only normal feed (growers' mash) and distilled water; Group B received 0.2 mg/kg bw of tramadol and 0.2 mg/kg bw of codeine, feed, and distilled water; Group C received 0.2 mg/kg bw of tramadol and 0.2 mg/kg bw of rohypnol; Group D received 0.2 mg/kg bw of codeine (6 weeks); and Group E received 0.2 mg/kg bw of tramadol and 0.2 mg/kg bw of rohypnohypnol; and 0.2 mg/kg bw of C. nucifera The animals were weighed, euthanized, and sacrificed, after which the serum was collected and the lungs, heart, and brain tissues were harvested and fixed for histological processing. Alterations were seen in the tested groups; there were congested vessels in the lungs, degenerative cells around the white matter, and congestive coronary arteries in the heart, aside from group five. C. nucifera was able to alleviate the damaging effects of the narcotics, possibly due to its rich phytonutrients.

Keywords: Cocus nucifera; Narcotics; Opioid; Lungs; Heart; Rats

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Citation

Citation: Nosa T Omorodion., et al. “Histomorphological Studies on the Therapeutic Potential of Cocos nucifera (Coconut) on Selected Narcotics Induced Toxicity of the Lungs and Heart of Albino Rat".Acta Scientific Veterinary Sciences 6.3 (2024): 54-63.

Copyright

Copyright: © 2024 Kundave VR., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.