Erudit-NDONGO KATENGO*, Gaël-NZUZI MAVUNGU, Fabien-MURHULA BAKENGA, Paul-MOBINZO KAPAY SOLEY and Victor-OKOMBE EMBEYA

Department of Pharmacology, Therapeutics and Toxicology, Faculty of Veterinary Medicine, University of Lubumbashi, DR Congo

*Corresponding Author: Erudit-NDONGO KATENGO, Department of Pharmacology, Therapeutics and Toxicology, Faculty of Veterinary Medicine, University of Lubumbashi, DR Congo.

Received: July 03, 2023; Published: July 29, 2023

Abstract

Gastrointestinal parasitism is a major health problem that affects the productivity of goat farming in the Lubumbashi region. The breeding of small ruminants in this region encounters difficulties related in particular to the management of the herd and the management of diseases such as gastrointestinal verminosis. For a long time, the fight against animal diseases, including verminosis, has been carried out with the use of synthetic chemical molecules. This poorly used chemical control would be at the origin of the development of resistance of certain pathogens. Faced with this constraint, it was planned to study the prevalence of parasitic infestations of GIS, their intensity and to evaluate in vitro the effectiveness of some anthelmintics on the predominant strongyle (Haemonchus contortus).
The collection of faecal specimens took place over three months, samples were taken in hasard from 480 goats in slaughter and adult worms (Haemonchus contortus) were taken from the abomasum of slaughtered goats.
Qualitative coproscopy was done using Willis' flotation method and quantitative coproscopy using MacMaster's method. It appears from this study that out of a total of 480 goats from which we collected, 360 were infested, a prevalence of 70%. As for the parasitic intensity, the results of this study reveal that Haemonchus contortus was found in 312 samples out of the 480 or (92.9%) followed by Trichostrongylus colubriformis found in 152 samples out of the 480 or (45.2%) and Moniezia spp d years 137 samples on the whole or (40.8%) and at the bottom of the scale Oesophagostomum columbianum 43 on the 480 or (12.8%).
The quantification of the different species of parasitic nematodes diagnosed during the present study in terms of OPG (Egg per gram faeces), reveals that Haemonchus contortus represents a much larger average of eggs in faeces (3988.6 ± 150.0) while Oesophagostomum columbianum has minimum values (483.7 ± 89.9), Haemonchus contortus is among the nematos of the most prolific. However, in the majority of cases, it was a multi-parasitism.
The efficacy of (albendazole, levamisole and oxyclozanide) was tested in vitro at concentrations 2.0; 1.0; 0.5; 0.25; 0.125 mg/ mL. At the first three concentrations, all extracts showed significant differences from negative controls (DMSO and PBS). As a result, levamisole was more effective at concentrations of 2 milligrams and 1 milligram per milliliter (90 and 84%) with statistically significant differences compared to the other two drugs. For the three drugs tested, larval paralysis was observed only with the first three concentrations, i.e., 2, 1 and 0.5 milligrams per milliliter.

Keywords: Prevalence; Gastrointestinal Strongyle; Goat; Anthelmintic; Lubumbashi

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Citation

Citation: Erudit-NDONGO KATENGO., et al. “Prevalence of Gastrointestinal Strongyle Infestations and In Vitro Evaluation of the Efficacy of the Three Anthelmintics on Haemonchus Contortus, Cases of Albendazole, Levamisole and Oxyclozanide in Goats in Supply Markets and in Public Slaughterhouses in Lubumbashi".Acta Scientific Veterinary Sciences 5.8 (2023): 85-92.

Copyright

Copyright: © 2023 Erudit-NDONGO KATENGO., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.