Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Review Article Volume 5 Issue 7

Canine Circovirus: An Emerging Pathogen of Dogs

Himani Ravi*, Ankita Awasthi, Prasenjit Dhar, Subhash Verma, Monika Bharadwaj and Rajesh Chahota

Department of Veterinary Microbiology, DGCN College of Veterinary and Animal Sciences, CSK HP University Palampur, Himachal Pradesh, India

*Corresponding Author: Himani Ravi, Department of Veterinary Microbiology, DGCN College of Veterinary and Animal Sciences, CSK HP University Palampur, Himachal Pradesh, India.

Received: June 05, 2023; Published: June 27, 2023

Abstract

Canine Circovirus is a new pathogen affecting dogs and is gaining rapid clinical importance. Its relationship to Canine Parvovirus-2 (CPV-2) and virus associated with gastrointestinal issues such as vomiting, diarrhoea, and haemorrhagic enteritis/gastro-enteritis in dogs are still in nascent stage. Canine CV has been found in several internal organs of domestic dogs as well as wild canids (wolves, foxes, etc.), implying widespread nature of the virus Although pathogenic potential of the virus is still not fully known. Canine CV has been hypothesised to circulate and aggravate the clinical course of other canine viral disesaes like Canine Parvovirus, Canine Distemper Virus, Canine Retrovirus, etc. This review article seeks to out forward the most recent information on CanineCV including the morphology, replication, aetiology, epidemiology and various available diagnostic methods with preventive strategies including vaccines against Canine CV.

Keywords: Canine CV; ssDNA; Hemorrhagic Enteritis; Necrotizing Vasculitis; Rolling Circle Replication; RT PCR; Multiepitope Vaccine

References

  1. Allan GM and Ellis JA. “Porcine circoviruses: a review”. Journal of Veterinary Diagnostic Investigations 12 (2000): 3-14.
  2. Anderson A., et al. “Role of canine circovirus in dogs with acute hemorrhagic diarrhea”. Veterinary Record22 (2017): 542-542.
  3. De Arcangeli S., et al. “Genomic characterization of canine circovirus detected in red foxes (Vulpes vulpes) from Italy using a new real-time PCR assay”. Journal of Wildlife Diseases1 (2020): 239-242.
  4. Bexton S., et al. “Detection of circovirus in foxes with meningoencephalitis, United Kingdom, 2009-2013”. Emerging Infectious Diseases 21 (2015): 1205-1208.
  5. Biagini P., et al. “ (2011).
  6. Blinkova O., et al. “Frequent detection of highly diverse variants of cardiovirus, cosavirus, bocavirus, and circovirus in sewage samples collected in the United States”. Journal of Clinical Microbiology 47 (2009): 3507-3513.
  7. Binns SH., et al. “Development and validation of an ELISA to detect antibodies to Corynebacterium pseudotuberculosis in ovine sera”. Veterinary Microbiology1-3 (2007): 169-179.
  8. In: King AMQ., et al. “Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses. Elsevier, Philadelphia, PA (2012): 343-349.
  9. Cságola A., et al. “Genetic characterization of type 2 porcine circoviruses detected in Hungarian wild boars”. Archives of Virology3 (2006): 495-507.
  10. Cheung AK. “Porcine circovirus: transcription and DNA replication”. Virus Research 164 (2012): 46-53.
  11. Decaro N., et al. “Genomic characterization of a circovirus associated with fatal hemorrhagic enteritis in a dog, Italy”. PLoS One 9 (2014): e105909.
  12. Dankaona W., et al. “Epidemiology, genetic diversity, and association of canine circovirus infection in dogs with respiratory disease”. Scientific Reports1 (2022): 1-12.
  13. Ellis JA., et al. “Coinfection by porcine circoviruses and porcine parvovirus in pigs with naturally acquired postweaning multisystemic wasting syndrome”. Journal of Veterinary Diagnostic Investigation1 (2000): 21-27.
  14. Faurez F., et al. “Replication of porcine circoviruses”. Virology Journal 6 (2009): 60.
  15. Franzo G and Segalés J. “Circoviruses (Circoviridae)”. In Encyclopedia of Virology; Bamford, D.H., Zuckerman, M., Eds.; Elsevier Science: Amsterdam, The Netherlands (2020): 182-192.
  16. Ge J., et al. “Development and application of an indirect enzyme-linked immunosorbent assay based on recombinant capsid protein for the detection of mink circovirus infection”. BMC Veterinary Research1 (2018): 1-8.
  17. Gentil M., et al. “Prevalence of Dog circovirus in healthy and diarrhoeic dogs”. Tierarztl Prax Ausg K Kleintiere Heimtiere 45 (2017): 89-94.
  18. Hsu HS., et al. “The high detection rate of dog circovirus in diarrheal dogs”. BMC Veterinary Research1 (2016): 1-6.
  19. Heath L., et al. “Evidence of unique genotypes of beak and feather disease virus in southern Africa”. Journal of Virology17 (2004): 9277-9284.
  20. Hesse R., et al. “Evidence for recombination between PCV2a and PCV2b in the field”. Virus Research1-2 (2008): 201-207.
  21. Jain P., et al. “An immunoinformatics study: designing multivalent T-cell epitope vaccine against canine circovirus”. Journal of Genetic Engineering and Biotechnology1 (2021): 1-11.
  22. Kapoor A., et al. “Complete genome sequence of the first canine circovirus”. Journal of Virology 86 (2012): 7018.
  23. Kotsias F., et al. “Genomic characterization of canine circovirus associated with fatal disease in dogs in South America”. PLoS One6 (2019): e0218735.
  24. Kaushik V., et al. “Immunoinformatics-Aided Design and In Vivo Validation of a Peptide-Based Multiepitope Vaccine Targeting Canine Circovirus”. ACS Pharmacology and Translational Science8 (2022): 679-691.
  25. Li L., et al. “Multiple diverse circoviruses infect farm animals and are commonly found in human and chimpanzee feces”. Journal of Virology 84 (2010): 1674-1682.
  26. Li L., et al. “Circovirus in tissues of dogs with vasculitis and hemorrhage”. Emerging Infectious Diseases 19 (2013): 534-541.
  27. LQrincz M., et al. “Novel circovirus in European catfish (Silurusglanis)”. Archives of Virology 157 (2012): 1173-1176.
  28. Liu SN., et al. “Development of an indirect ELISA for the detection of duck circovirus infection in duck flocks”. Veterinary Microbiology1-2 (2010): 41-46.
  29. Meng XJ. “Spread like a wildfire-the omnipresence of porcine circovirus type 2 (PCV2) and its ever-expanding association with diseases in pigs”. Virus Research 164 (2012): 1-3.
  30. Manni F., et al. “Detecting recombination in TT virus: a phylogenetic approach”. Journal of Molecular Evolution5 (2002): 563-572.
  31. Ma CM., et al. “Evidence for recombination in natural populations of porcine circovirus type 2 in Hong Kong and mainland China”. Journal of General Virology6 (2007): 1733-1737.
  32. Martin DP., et al. “Recombination in eukaryotic single-stranded DNA viruses”. Viruses9 (2011): 1699-1738.
  33. Thaiwong T., et al. “Canine Circovirus 1 (CaCV-1) and Canine Parvovirus 2 (CPV-2) recurrent dual infections in a papillon breeding colony”. Veterinary Pathology6 (2016): 1204-1209.
  34. Olvera A., et al. “Molecular evolution of porcine circovirus type 2 genomes: phylogeny and clonality”. Virology2 (2007): 175-185.
  35. Olvera A., et al. “Comparison of porcine circovirus types 2 loads in serum quantified by a real-time PCR in postweaning multisystemic wasting syndrome and porcine dermatitis and nephropathy syndrome naturally affected pigs”. Journal of Virological Methods 117 (2004): 75-80.
  36. Opriessnig T and Halbur PG. “Concurrent infections are important for the expression of porcine circovirus-associated disease”. Virus Research 164 (2012): 20-32.
  37. Palinski R., et al. “A Novel Porcine Circovirus Distantly Related to Known Circoviruses Is Associated with Porcine Dermatitis and Nephropathy Syndrome and Reproductive Failure”. Journal of Virology 91 (2017).
  38. Pearodwong P., et al. “Prevalence of porcine circovirus-2 DNA positive ovarian and uterine tissues in gilts culled due to reproductive disturbance in Thailand”. Tropical Animal Health and Production 47 (2015): 833-840.
  39. Rosario K., et al. “Diverse circovirus-like genome architectures revealed by environmental metagenomics”. Journal of General Virology 90 (2009): 2418-2424.
  40. Scott AN., et al. “Serological diagnosis of goose circovirus infections”. Avian Pathology 35 (2006): 495-499.
  41. Segalés J. “Porcine circovirus type 2 (PCV2) infections: clinical signs, pathology and laboratory diagnosis”. Virus Research 164 (2012): 10-19.
  42. Shin MK., et al. “Assessing PCV2 antibodies in field pigs vaccinated with different porcine circovirus 2 vaccines using two commercial ELISA systems”. Journal of Veterinary Science 16 (2015): 25-29.
  43. Tarján ZL Pénzes JJ., et al. “First detection of Circo-like sequences in amphibians and novel putative circoviruses in fishes”. Acta Veterinarica Hungarica 62 (2014): 134- 144.
  44. Tischer I., et al. “Characterization of papovirus and picornaviruslike particles in permnanent pig kidney cell lines”. Zentralbl Bakteriol Orig A 226 (1974): 153-167.
  45. Todd D. “Avian circovirus diseases: lessons for the study of PMWS”. Veterinary Microbiology 98 (2004): 169-174.
  46. Tischer I., et al. “Replication of porcine circovirus: induction by glucosamine and cell cycle dependence”. Archives of Virology1 (1987): 39-57.
  47. Van den Brand JM., et al. “Metagenomic analysis of the viral flora of pine marten and European badger feces”. Journal of Virology 86 (2012): 2360-2365.
  48. Venkataramana M., et al. “Development of sandwich dot-ELISA for specific detection of Ochratoxin A and its application to contaminated cereal grains originating from India”. Frontiers in Microbiology6 (2015):
  49. Wang Z., et al. “Detection of antibodies against canine circovirus in naturally and experimentally infected canines by recombinant capsid enzyme-linked immunosorbent assay”. Frontiers in Veterinary Science 7 (2020):
  50. Weber MN., et al. “Characterization of dog serum virome from Northeastern Brazil”. Virology525 (2018): 192-199.
  51. Zaccaria G., et al. “Circovirus in domestic and wild carnivores: An important opportunistic agent?” Virology 490 (2016): 69-74.

Citation

Citation: Himani Ravi., et al. “Canine Circovirus: An Emerging Pathogen of Dogs".Acta Scientific Veterinary Sciences 5.7 (2023): 106-113.

Copyright

Copyright: © 2023 Himani Ravi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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