Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Review Article Volume 5 Issue 7

Clinicopathology, Liver Lipid Profiles, Oxidative and Antioxidant Biomarkers of Datura stramonium Leaf Extract Toxicity and Ameliorative Potentials of Moringa oleifera Leaf Extract in Wistar Rats

Saleh1*, MY Fatihu1, MM Suleiman2, KAN Esievo1 and JS Ibrahim1

1Department of Veterinary Pathology, Ahmadu Bello University (ABU), Zaria
2Department of Veterinary Pharmacology and Toxicology, ABU, Zaria

*Corresponding Author: Saleh, Department of Veterinary Pathology, Ahmadu Bello University (ABU), Zaria.

Received: May 15, 2023; Published: June 07, 2023

Abstract

There has been growing global concern over Datura stramonium toxicity in livestocks, pets and humans following ingestion of the plant. Effects of ethanol leaf extract D. stramonium (ELEDS) in liver lipid profiles, oxidative, antioxidant biomarkers and liver tissue of rats were investigated and possible ameliorative effects of ethanol leaf extract Moringa oleifera (ELEMO). Fifty adults male Wistar rats were randomly divided into five groups of 10 rats each. Group I were administered distilled water (2 mL/kg), group II; ELEMO (200 mg/kg), group III; ELEDS (170.4 mg/kg), group 1V; ELEDS+ELEMO and group V; ELEDS+ physostigmine (0.02 mg/kg). There was significant (P < 0.05) decrease in triglyceride and superoxide dismutase in ELEDS-treated groups compared to controls. Whereas, significant elevations were observed in high-density lipoprotein-cholesterol and malondialdehyde compared to controls. Microscopically, the liver of rats in ELEDS- treated group showed congestion and necrosis. Values in ELEDS+ELEMO-treated groups were comparable (P > 0.05) to controls. The ability of ELEMO (200 mg/kg) to ameliorate changes in lipid profile, peroxidation and antioxidant, caused by D. stramonium (170.4 mg/kg) is suggestive of a novel finding. This finding may be useful especially in areas where animals are prone to D. stramonium toxicity with poor accessibility to antidote.

Keywords: Datura; Lipid Profile; Peroxidation; Antioxidant; Moringa

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Citation

Citation: Saleh.,et al. “Clinicopathology, Liver Lipid Profiles, Oxidative and Antioxidant Biomarkers of Datura stramonium Leaf Extract Toxicity and Ameliorative Potentials of Moringa oleifera Leaf Extract in Wistar Rats".Acta Scientific Veterinary Sciences 5.7 (2023): 27-37.

Copyright

Copyright: © 2023 Saleh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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