Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Review Article Volume 5 Issue 7

Animal Models of Neurodegenerative Disorders

SApeksha Khare1*, Amita Dubey2, Yamini Verma3, Amita Tiwari2, Yash Kumar Verma1 and Itherineni Karthik1

1MVSc Scholar, Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, Nanaji Deshmukh Veterinary Science University, Jabalpur, Madhya Pradesh, India
2Associate Professor, Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, Nanaji Deshmukh Veterinary Science University, Jabalpur, Madhya Pradesh, India
3Professor and Head, Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, Nanaji Deshmukh Veterinary Science University, Jabalpur, Madhya Pradesh, India

*Corresponding Author: Apeksha Khare, MVSc Scholar, Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, Nanaji Deshmukh Veterinary Science University, Jabalpur, Madhya Pradesh, India.

Received: May 15, 2023; Published: June 02, 2023


Neurodegenerative diseases are neurological disorders of the central and peripheral nervous systems increasingly observed in older animals. These diseases result in progressive loss of neuronal function and behavioral changes are the most common cause of dementia in older animals as well as humans. For the advancement of basic understanding of these diseases, various in-vitro and in-vivo models have been used. Animal models are living organisms, which mimic the pathophysiology of the original animals in a very precise manner. Such models are designed to replicate the underlying causes, pathological lesions, symptoms, and potential therapeutic options for the disorders being studied. Selection of an appropriate model with respect to a particular aspect of the neurodegenerative diseases in the most scientific, ethical and legal way is crucial. Various natural, induced, negative, transgenic and orphan models of commonly occurring neurodegenerative diseases developed so far are discussed in this review.

Keywords: Animal Models; Neurodegenerative Diseases; Transgenic, Alzheimer’s; Prions; Spinal Muscular Atrophy; Mice; Rats


  1. Barnes Richard and Clarence Lehman. "Modeling of bovine spongiform encephalopathy in a two-species feedback loop”. Epidemics2 (2013): 85-91.
  2. Chen Yanxing., et al. "A non-transgenic mouse model (icv-STZ mouse) of Alzheimer’s disease: similarities to and differences from the transgenic model (3xTg-AD mouse)”. Molecular Neurobiology47 (2013): 711-725.
  3. Collins Steven J., et al. "Transmissible spongiform encephalopathies”. The Lancet9402 (2004): 51-61.
  4. Dewey Curtis Wells., et al. "Canine cognitive dysfunction: pathophysiology, diagnosis, and treatment”. Veterinary Clinics: Small Animal Practice3 (2019): 477-499.
  5. Ericsson Aaron C., et al. "A brief history of animal modeling”. Missouri Medicine3 (2013): 201.
  6. Farah Idle O., et al. "An overview of animal models in experimental schistosomiasis and refinements in the use of non-human primates”. Laboratory Animals3 (2001): 205-212.
  7. Fisher Elizabeth MC and David M Bannerman. "Mouse models of neurodegeneration: Know your question, know your mouse”. Science Translational Medicine493 (2019): eaaq1818.
  8. Franco Nuno Henrique. "Animal experiments in biomedical research: a historical perspective”. Animals1 (2013): 238-273.
  9. Gama Sosa Miguel A., et al. "Animal transgenesis: an overview”. Brain Structure and Function214 (2010): 91-109.
  10. Geda Yonas E., et al. "Physical exercise, aging, and mild cognitive impairment: a population-based study”. Archives of Neurology1 (2010): 80-86.
  11. Harlan Laboratories. Research models: athymic nude mouse online (2009).
  12. Hau Jann and Steven J Schapiro. "Handbook of laboratory animal science, volume II: Animal models”. (2011): 1-9.
  13. Held J R. "Muhlbock memorial lecture: Considerations in the provision and characterization of animal models”. Animal Quality and Models in Biomedical Research, 7th ICLAS Symposium Utrecht. (1979).
  14. Holtze Susanne., et al. "Alternative animal models of aging research”. Frontiers in Molecular Biosciences8 (2021): 660959.
  15. Iancu Ruxandra., et al. "Behavioral characterization of a unilateral 6-OHDA-lesion model of Parkinson's disease in mice”. Behavioural Brain Research1 (2005): 1-10.
  16. Iijima-Ando Kanae and Koichi Iijima. "Transgenic Drosophila models of Alzheimer’s disease and tauopathies”. Brain Structure and Function214 (2010): 245-262.
  17. Jackson Alan C and Hannah Park. "Experimental rabies virus infection of p75 neurotrophin receptor-deficient mice”. Acta Neuropathologica6 (1999): 641-644.
  18. Jucker Mathias. "The benefits and limitations of animal models for translational research in neurodegenerative diseases”. Nature Medicine11 (2010): 1210-1214.
  19. Li Hong‐, et al. "Current state of research on non‐human primate models of Alzheimer’s disease”.Animal Models and Experimental Medicine 2.4 (2019): 227-238.
  20. Málaga-Trillo Edward., et al. "Fish models in prion biology: underwater issues”. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease3 (2011): 402-414.
  21. Monani Umrao R., et al. "Animal models of spinal muscular atrophy”. Human Molecular Genetics16 (2000): 2451-2457.
  22. Prabhakar Sharma. "Translational research challenges: finding the right animal models”. Journal of Investigative Medicine8 (2012): 1141-1146.
  23. Ribeiro Fabiola Mara., et al. "Animal models of neurodegenerative diseases”. Brazilian Journal of Psychiatry35 (2013): S82-S91.
  24. Robinson Richard K. “Encyclopedia of food microbiology”. Academic press, (2014).
  25. Scheyer A. “Murine models of neurodegenerative disease online” (2019).
  26. Schonecker B. “Students guide to animal models”. 2nd Denmark: Frydenskrig Forlag; (2014): 2-19.
  27. Scott M R., et al. “Transgenic models of prion disease”. Springer Vienna, (2000).
  28. Selkoe Dennis J and John Hardy. "The amyloid hypothesis of Alzheimer's disease at 25 years”. EMBO Molecular Medicine6 (2016): 595-608.
  29. Siso Silvia., et al. "Neurodegenerative diseases in domestic animals: a comparative review”. The Veterinary Journal1 (2006): 20-38.
  30. Vidal C., et al. "Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy”. Neuroscience4 (2009): 731-743.
  31. Von Messling Veronika., et al. "A ferret model of canine distemper virus virulence and immunosuppression”. Journal of Virology23 (2003): 12579-12591.
  32. Wessler S. "Animal models of thrombosis and hemorrhagic disease”. DHEW Pub. No. NIH76982 (1976).
  33. Wolozin Benjamin., et al. "Watching worms whither: modeling neurodegeneration in C. elegans”. Progress in Molecular Biology and Translational Science100 (2011): 499-514.
  34. Zeng Xian-Si., et al. "Cellular and molecular basis of neurodegeneration in Parkinson disease”. Frontiers in Aging Neuroscience10 (2018): 109.


Citation: Apeksha Khare.,et al. “Animal Models of Neurodegenerative Disorders".Acta Scientific Veterinary Sciences 5.7 (2022): 03-10.


Copyright: © 2022 Apeksha Khare.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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