SApeksha Khare¹*, Amita Dubey², Yamini Verma³, Amita Tiwari², Yash Kumar Verma¹ and Itherineni Karthik¹

¹MVSc Scholar, Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, Nanaji Deshmukh Veterinary Science University, Jabalpur, Madhya Pradesh, India
²Associate Professor, Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, Nanaji Deshmukh Veterinary Science University, Jabalpur, Madhya Pradesh, India
³Professor and Head, Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, Nanaji Deshmukh Veterinary Science University, Jabalpur, Madhya Pradesh, India

*Corresponding Author: Apeksha Khare, MVSc Scholar, Department of Veterinary Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, Nanaji Deshmukh Veterinary Science University, Jabalpur, Madhya Pradesh, India.

Received: May 15, 2023; Published: June 02, 2023

Abstract

Neurodegenerative diseases are neurological disorders of the central and peripheral nervous systems increasingly observed in older animals. These diseases result in progressive loss of neuronal function and behavioral changes are the most common cause of dementia in older animals as well as humans. For the advancement of basic understanding of these diseases, various in-vitro and in-vivo models have been used. Animal models are living organisms, which mimic the pathophysiology of the original animals in a very precise manner. Such models are designed to replicate the underlying causes, pathological lesions, symptoms, and potential therapeutic options for the disorders being studied. Selection of an appropriate model with respect to a particular aspect of the neurodegenerative diseases in the most scientific, ethical and legal way is crucial. Various natural, induced, negative, transgenic and orphan models of commonly occurring neurodegenerative diseases developed so far are discussed in this review.

Keywords: Animal Models; Neurodegenerative Diseases; Transgenic, Alzheimer’s; Prions; Spinal Muscular Atrophy; Mice; Rats

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Citation

Citation: Apeksha Khare.,et al. “Animal Models of Neurodegenerative Disorders".Acta Scientific Veterinary Sciences 5.7 (2022): 03-10.

Copyright

Copyright: © 2022 Apeksha Khare.,et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.