Acta Scientific Agriculture (ASAG)(ISSN: 2581-365X)

Short Communication Volume 5 Issue 6

Kruppel Like Factor and Endothelial Dysfunctions

Sheikh Uzma Farooq1 and Aditya Sharma2*

1Department of Veterinary Pharmacology and Toxicology, Khalsa College of Veterinary and Animal Sciences, Amritsar, India
2Department of Veterinary Pathology, Khalsa College of Veterinary and Animal Sciences, Amritsar, India

*Corresponding Author: Aditya Sharma, Assistant Professor, Department of Veterinary Pathology, KCVAS, Amritsar, Punjab, India.

Received: May 22, 2023; Published: May 30, 2023

Abstract

Atherosclerosis is a chronic progressive disease caused by vascular injury, and is induced by the interaction of various inflammatory cells and mediators. The Kruppel-like factor 4 (KLF4) is an important transcription factor that has a role in cell growth, differentiation, proliferation, and regulation of cardiovascular disease. It is gained interest of scientist as KLF4, in particular, plays an important role in the pathogenesis of atherosclerosis.KLF4 may be an important “molecular switch” and is being used as biomarker and therapeutic targetin atherosclerosis and vascular disease.

Keywords: Kruppel Like Factor; KLF4; Atherosclerosis; Cardiovascular Disease

References

  1. Yoshida T and M Hayashi. “Role of Krüppel-Like Factor 4 and its Binding Proteins in Vascular Disease”. Journal of Atherosclerosis and Thrombosis5 (2014): 402-413.
  2. Zheng X., et al. “Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells”. Biochemical and Biophysical Research Communications4 (2013): 625-631.
  3. Hansson GK. “Inflammation, atherosclerosis, and coronary artery disease”. The New England Journal of Medicine 16 (2005): 1685-1695.
  4. N S., et al. “Myeloid Krüppel-like factor 4 deficiency augments atherogenesis in ApoE-/- mice--brief report”. Arteriosclerosis, Thrombosis, and Vascular Biology12 (2012): 2836-2838.
  5. Lavigne MC., et al. “Growth and phenotypic characterization of porcine coronary artery smooth muscle cells”. In Vitro Cellular and Developmental Biology – Animal3 (1999): 136-143.
  6. Goikuria H., et al. “Characterization of Carotid Smooth Muscle Cells during Phenotypic Transition”. Cells 3 (2018).
  7. Wang TM., et al. “microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype”. Journal of Cellular and Molecular Medicine12 (2017): 3592-3601.
  8. Zheng B., et al. “Role of Kruppel-like factor 4 in phenotypic switching and proliferation of vascular smooth muscle cells”. IUBMB Life2 (2010): 132-139.

Citation

Citation: Sheikh Uzma Farooq and Aditya Sharma. “Kruppel Like Factor and Endothelial Dysfunctions". Acta Scientific Veterinary Sciences 5.6 (2023): 80-82.

Copyright

Copyright: © 2023 Sheikh Uzma Farooq and Aditya Sharma. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.008

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