Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Short Communication Volume 5 Issue 3

Biochemical and Hematological Studies of a Local Indigenous Alcohol Beverage in male albino Rats

Bot Yakubu Sunday1*, Vidya Sankarapandian1, Emmanuel Ifeanyi Obeagu1, Anslem Ajugwo1, Patricia Oluchi Okezie2, Nwanjo Harrison U3, Nwosu Dennis C3 and Bot David Yakubu4

1 Department of Medical Laboratory Science, Faculty of Health Sciences, Kampala International University, Uganda
2Department of Chemical Pathology, Federal College of Veterinary and Medical Laboratory Technology, Vom Plateau State, Nigeria
3Department of Chemical Pathology, Imo State University, Owerri, Nigeria
4Faculty of Health Sciences and Technology, Department of Chemical Pathology, University of Jos, Nigeria

*Corresponding Author: Bot Yakubu Sunday, Department of Medical Laboratory Science, Faculty of Health Sciences, Kampala International University, Uganda.

Received: January 24, 2023; Published: February 24, 2023

Abstract

Goskolo (GSK) is a newly introduced local alcoholic drink on the Plateau with several negative impacts among the youths. Currently, there is paucity of scientific information on the content of GSK and the identity of its content remains unknown to the public. This study is aimed at investigating the Gas Chromatography and Mass Spectrometry, (Chromatographic profiling) of GSK, and its Biochemical, Hematological and Histological effects in adult male Wister Albino rats. Four (4) brands of commercially produced GSK beverages tagged Dark Rum “DR”, Alomo Bitters “AB”, Swagga Schnnaps “SS” and Swagga Dry Din “SDG” were procured from retail stops (Local suppliers). Sample was analyzed using Gas Chromatography and Mass Spectrometry (GC-MS) method. Fifty (50) adult male Wister Albino rats were randomly divided into groups of ten (10) rats each. Animals were sacrificed by Chloroform inhalation at the end of thirty days. Necroscopy was performed on all the animals. Blood samples were also collected and serum levels of Glucose, Total bilirubin (TB), Alanine Transaminase (AST), Total Protein (TP), Albumin (Alb), Gammaglutamyl Transferase (GGT), Alkaline Phosphatase (ALP), Malondialdehyde (MDA),White Blood Cells (WBC’s), Red Blood Cells (RBC’s), Packed Cell Volume (PCV), Platelets (Plt), Hemoglobin (Hb), Mean Cell Volume (MCV), Mean Cell Hemoglobin (MCH), Mean Cell Hemoglobin Concentration (MCHC) were all analysed using standard methods. The biochemical parameters revealed marked increased levels of ALT, AST, GGT, and MDA. Particularly among treated animals in groups 4 and 5 when compared to the control (Group 1). However, Creatinine values were significantly increased in group 2, 4 and 5 (581.18 ± 1.36μmol/L; 653.86 ± 0.59μmol/L; 560.99 ± 0.15μmol/L) as against the control (531.93 ± 0.9μmol/L). Conversely, serum levels of Albumin, Total protein and Glucose were reduced statistically (p < 0.05). The hematological variables also revealed significant difference in average values of RBC’s, PCV, MCH, MCHC, Hb, Neutrophils and Monocytes which were reduced in various groups. Significantly higher values of WBC (16.27 ± 0.09x109/L; 14.30 ± 0.06x109/L) and MCV (63.70 ± 0.42FL) were seen in animals treated with (“SS”) and (“SDG”) respectively.

Keywords: Wister Albino Rat; Alomo Bitters; Swagga Schnnaps; Swagga Dry Din; Biochemical; Hematological Parameters

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Citation

Citation: Bot Yakubu Sunday., et al. “Some Biochemical and Hematological Studies of a Local Indigenous Alcohol Beverage in Male Albino Rats".Acta Scientific Veterinary Sciences 5.3 (2023): 56-63.

Copyright

Copyright: © 2023 Bot Yakubu Sunday., et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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