Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Research Article Volume 5 Issue 3

Network analysis of beta casomorphin-7 revealed genes and pathways associated with human diseases

Kanaka KK1#, Nidhi Sukhija1#*, Nibedita Nayak2, Rangasai Chandra Goli1, Amiya Ranjan Sahu2 and Subrata Koloi1

10ICAR-National Dairy Research Institute, Karnal, India
2ICAR-Central Coastal Agricultural Research Institute, Goa, India
#First two authors contributed equally to the paper

*Corresponding Author: Nidhi Sukhija, ICAR-National Dairy Research Institute, Karnal, India.

Received: January 30, 2023; Published: February 13, 2023

Abstract

Context: Several epidemiological researches imply a link between exposure to A1 beta casein (BC) containing milk and the incidence of non-communicable diseases in humans. Many breeding policies support BC variants not releasing Beta Casomorphin-7 (BCM-7).

Objective: Insilico network analysis was performed to determine the bioactive targets, pathways and diseases associated with A1 and A2 beta casein and BCM-7.

Results: The analysis revealed 63 bioactive targets for A1 and A2 beta casein with 118 pathways and 30 diseases associated. There were no differences in bioactive targets between A1 and A2 beta casein. For BCM-7, 15 bioactive targets were identified, which were found to be associated with 18 pathways and 4 diseases.

Conclusion: The results showed that the change in amino acid at the 67th position in A1 and A2 beta casein did not affect the bioactive targets. BCM-7 may be held responsible for adverse effects until challenged by clinical trials.

Keywords: Beta Casein; Beta Casomorphin-7; A1 Milk; Human Disease

References

  1. Roginski H. “Encyclopedia of dairy sciences”. Academic Press, London (2003).
  2. El-Agamy EI. “The challenge of cow milk protein allergy”. Small Ruminant Research1-2 (2007): 64-72.
  3. Farrell HM., et al. “Nomenclature of the proteins of cows’ milk-sixth revision”. Journal of Dairy Science 87 (2004): 1641-1674.
  4. Kaskous S. “A1-and A2-Milk and Their Effect on Human Health”. Journal of Food Engineering and Technology 9 (2020).
  5. Hegde N. “Research on A1 and A2 milk: A1 milk is not a matter of health concern”. The Indian Journal of Animal Sciences 89 (2019).
  6. Kohl M., et al. “Cytoscape: software for visualization and analysis of biological networks”. Data Mining in Proteomics: from Standards to Applications (2011): 291-303.
  7. Stewart AF., et al. “Complete nucleotide sequences of bovine alpha S2-and beta-casein cDNAs: comparisons with related sequences in other species”. Molecular Biology and Evolution3 (1987): 231-241.
  8. Schaefer C and Rost B. “Predict impact of single amino acid change upon protein structure”. BMC Genomics4 (2012): S4.
  9. Ng PC and Henikoff S. “Predicting the effects of amino acid substitutions on protein function”. Annual Review of Genomics and Human Genetics 7 (2006): 61-80.
  10. Elliott RB., et al. “Type I (insulin dependent) diabetes mellitus and cow milk: casein variant consumption”. Diabetologia 42 (1999): 292-296.
  11. Kostyra E., et al. “Opioid peptides derived from milk proteins”. Polish Journal of Food and Nutrition Sciences 54 (2004): 25-35.
  12. Chang WH., et al. “β-Casomorphin increases fat deposition in broiler chickens by modulating expression of lipid metabolism genes”. Animal4 (2019): 777-783.
  13. Després JP. “Body fat distribution and risk of cardiovascular disease: an update”. Circulation 10 (2012): 1301-1313.
  14. Ravussin E and Smith SR. “Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus”. Annals of the New York Academy of Sciences1 (2002): 363-378.
  15. Hauner H. “Obesity and diabetes”. Textbook of diabetes (2017): 215-228.
  16. Kuellenberg de Gaudry D., et al. “A1- and A2 beta-casein on health-related outcomes: A scoping review of animal studies”. European Journal of Nutrition1 (2022): 1-21.
  17. Lucarelli S., et al. “Food allergy and infantile autism”. Panminerva Medicine3 (1995): 13741.
  18. Reichelt KL and Knivsberg AM. “Can the pathophysiology of autism be explained by the nature of the discovered urine peptides?” Nutritional Neuroscience1 (2003): 19-28.
  19. “Scientific Report of EFSA prepared by a DATEX Working Group on the Potential Health Impact of β-Casomorphins and Related Peptides”. European Food Safety Authority Science Report (2009): 1-107.
  20. Arnarson A. “A1 vs. A2 milk- Does it matter?” (2019).
  21. Kost NV., et al. “Beta-casomorphins-7 in infants on different type of feeding and different levels of psychomotor development”. Peptides10 (2009): 1854-1860.
  22. Wasilewska J., et al. “The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life-threatening events (ALTE)”. Neuropeptides3 (2011): 189-195.
  23. Chowdhury R., et al. “Breastfeeding and maternal health outcomes: A systematic review and meta-analysis”. Acta Paediatric 104 (2015): 96-113.
  24. Summer A., et al. “Occurrence, biological properties and potential effects on human health of β-casomorphin 7: Current knowledge and concerns”. Critical Reviews in Food Science and Nutrition21 (2020): 3705-3723.

Citation

Citation: Nidhi Sukhija., et al. “Network analysis of beta casomorphin-7 revealed genes and pathways associated with human diseases". Acta Scientific Veterinary Sciences 5.3 (2023): 31-46.

Copyright

Copyright: © 2023 Nidhi Sukhija., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.008

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US