Network analysis of beta casomorphin-7 revealed genes and pathways
associated with human diseases
Kanaka KK1#, Nidhi Sukhija1#*, Nibedita Nayak2, Rangasai Chandra Goli1,
Amiya Ranjan Sahu2 and Subrata Koloi1
10ICAR-National Dairy Research Institute, Karnal, India
2ICAR-Central Coastal Agricultural Research Institute, Goa, India
#First two authors contributed equally to the paper
*Corresponding Author: Nidhi Sukhija, ICAR-National Dairy Research Institute,
January 30, 2023; Published: February 13, 2023
Context: Several epidemiological researches imply a link between exposure to A1 beta casein (BC) containing milk and the incidence of non-communicable diseases in humans. Many breeding policies support BC variants not releasing Beta Casomorphin-7 (BCM-7).
Objective: Insilico network analysis was performed to determine the bioactive targets, pathways and diseases associated with A1 and A2 beta casein and BCM-7.
Results: The analysis revealed 63 bioactive targets for A1 and A2 beta casein with 118 pathways and 30 diseases associated. There were no differences in bioactive targets between A1 and A2 beta casein. For BCM-7, 15 bioactive targets were identified, which were found to be associated with 18 pathways and 4 diseases.
Conclusion: The results showed that the change in amino acid at the 67th position in A1 and A2 beta casein did not affect the bioactive targets. BCM-7 may be held responsible for adverse effects until challenged by clinical trials.
Keywords: Beta Casein; Beta Casomorphin-7; A1 Milk; Human Disease
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