Accelerated Cross-Linking for the Treatment of Chronic Corneal Ulcers and Evaluation
of Healing with Optical Coherence Tomography (OCT)
Rolando Arcelli1, Chiara Ovidi6, Caterina Morera1*, Giuseppe Lombardo2,3, Marco Lombardo3,4, Andrea Marchegiani5 and Rodolfo Gialletti1
1Department of Veterinary Medicine, Università degli studi di Perugia, Via San Costanzo, Perugia, Italy
2CNR-IPCF, Istituto Per i Processi Chimico-Fisici, Viale F. Stagno D’Alcontres, Messina, Italy
3Vision Engineering Italy SRL, Via Livenza, Rome, Italy
4Studio Italiano di Oftalmologia, Via Livenza, Rome, Italy
5School of Biosciences and Veterinary Medicine, University of Camerino, Via Circonvallazione, Matelica (Macerata), Italy
6Doctor of Veterinary Medicine Freelancer, Italy
*Corresponding Author: Caterina Morera, Department of Veterinary Medicine,
Università degli studi di Perugia, Via San Costanzo, Perugia, Italy.
December 05, 2022; Published: January 07, 2022
Purpose: To assess the epithelial-stromal healing process after corneal phototherapy with riboflavin and UV-A of corneal ulcers, which were resistant to medical therapy, by means of Anterior Segment Optical Coherence Tomography (OCT; iVue optovue).
Procedure: 14 dogs (14 eyes), with corneal ulcer involving at least 1/3 of the stroma and not responding to medical therapy for at least 30 days, were included in this study. The corneal phototherapy consisted in the instillation of 0.1% riboflavin ophthalmic so lution on to the cornea for 20 minutes, followed by UV-A irradiation at 30 mW/cm2 for 3 minutes. Subjects underwent a complete ophthalmological examination on the day of treatment, after 7 days and then at an interval between 7 and 20 days until the resolution of the ulcer for a follow-up period up to 3 months. At each follow-up examination, the stromal and epithelial thickness of both the ulcerated area and the surrounding healthy areas were measured with OCT in order to evaluate the epithelial-stromal healing process.
Results: Healing of the ulcerative corneal lesion was achieved in 12.5 ± 4 days after corneal phototherapy in all cases. The OCT assessment of corneal lesions was valuable to assess objectively the course of the healing process.
Conclusions: OCT assessment provided useful information on corneal wound healing process after corneal phototherapy. The treatment has proven to be a safe and valid therapeutic option for chronic corneal ulcers no responders to medical therapy
Keywords: Corneal Phototherapy; Corneal Cross-Linking; UV-A; Riboflavin; Corneal Ulcers; OCT
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