Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Short Communication Volume 4 Issue 12

Short Communication on Infectious Ectromelia

Sheikh Uzma Farooq1, Aditya Sharma2* and Varun Khajuria3

1Department of Veterinary Pharmacology and Toxicology, Khalsa College of Veterinary Sciences, Amritsar, India
2Department of Veterinary Pathology, Khalsa College of Veterinary Sciences, Amritsar, India
3Department of Veterinary Parasitology, Khalsa College of Veterinary Sciences, Amritsar, India

*Corresponding Author: Aditya Sharma, Department of Veterinary Pathology, Khalsa College of Veterinary Sciences, Amritsar, India.

Received: November 01, 2022; Published: November 02, 2022


Infectious ectromelia (ECTV) is an infectious viral disease caused by dsDNA virus of poxviridae family. It is an acute, systemic, highly lethal disease of mice. Highly susceptible strains of mice die without shedding the virus but the intermediate susceptible strains recover from infection and shed the virus. It is spread due to direct contact from animal to animal. The spread of disease through shipment of laboratory mice has been reported. It has genetic similarity with variola virus and other subspecies of poxviridae family. The ECTV mouse model is used by researchers to understand the virus–host relationship, elucidate mechanism of viral pathogenesis and modulate host response. It has also been used as a model for smallpox virus and for testing orthopoxvirus antivirals and vaccines. The mouse pox virus gained attention as super mouse pox virus, which is genomic alteration of mouse pox virus in the C57BL/6 strain of mice. The recombinant virus altered host immune response and caused lethal infection in exposed population as well as re-infected previously immunized population. It can pose threat to immunized population in nearby future if used as biological weapon.

Keywords: Infectious Ectromelia; dsDNA Virus; Poxviridae; C57BL/6 Strain


  1. Andrewes CH and Elford WJ. “Infectious ectromelia: experiments on interference and immunisation”. British Journal of Experimental Pathology 28 (1947): 278-285.
  2. Buller RML., et al. “Efficacy of oral active ether lipid analogs of cidofovir in a lethal mousepox model”. Virology 318(2004): 474-481.
  3. Dick EJ., et al. “Mousepox outbreak in a laboratory mouse colony”. Laboratory Animal Science 46 (1996): 602-611.
  4. Marchal J. “Infectious ectromelia. A hitherto undescribed virus disease of mice”. The Journal of Pathology 33 (1930): 713-728.


Citation: Aditya Sharma., et al. “Short Communication on Infectious Ectromelia". Acta Scientific Veterinary Sciences 4.12 (2022): 13-15.


Copyright: © 2022 Aditya Sharma., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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