Shikha Yadav¹, Bilal Ur Rehman³, Mohammad Ahmad Khan² and Vijay Pal Singh³

¹National Institute of Biologicals, Noida, India ²Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India ³CSIR-Institute of Genomics and Integrative Biology, New Delhi, India

*Corresponding Author:Vijay Pal Singh, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.

Received: October 04, 2022; Published: October 18, 2022

Abstract

Milk is considered to be a complete dietary food that is consumed all over the world as a protein source. It has various proteins among which A1 and A2 variants of Beta-casein are the major varieties. Amidst them, A1 is believed to possess health issues. One of its metabolite Beta-CasoMorphin-7 (BCM7) is becoming a research point of interest among the scientific community. As the intestine is the site where maximum absorption of milk takes place, exploration of this intestinal tissue is a must. Along with it we also observed Heart and Spleen tissues for the effects of milk but there was no pathological change found in these organs. Histopathology is the key technique that has been used in our study to demonstrate the influence of A1 and A2 milk on the intestine. The goal of our study was to establish any possible relationship between the intestinal health of BALB/c mice and the consumption of milk containing A1A1 beta casein variants while no pathological changes were found in mice fed with the A2A2 variants of Beta casein. To our understanding, this is the opening study showing increased intestinal accessibility and villi atrophy in all the mice given with A1A1 milk which in turn may lead to nutrient deficiency and further health issues in these mice. In contrast, no pathological changes were found in the control mice and in those that were administered with the A2A2 Beta casein variant of cow milk.

Keywords: A1A1 and A2A2; Beta-Casomorphine7 (BCM7); Villous Atrophy; Intestinal Permeability

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Citation

Citation: Vijay Pal Singh., et al. “Effects of A1A1 and A2A2 Casein in Cow's Milk on Mice Intestine, Heart, and Spleen". Acta Scientific Veterinary Sciences 4.11 (2022): 117-120.

Copyright

Copyright: © 2022 Noura Mohammed Almaimouni., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.