Noura Mohammed Almaimouni¹*, Moustafa Hussein Roshdy Elnaggar^1,2, Mansour Attia Al-Hazmi¹ and Hassan Mohamed Heba¹

¹Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, Saudi Arabia
²Department of Zoology, Faculty of Sciences, Suez Canal University, Ismailia, Egypt

*Corresponding Author:Aashiq Hussain, AGM - Technical (AHN), Department of Animal Husbandry and Nutrition, Rossari Biotech Limited, India.

Received: October 04, 2022; Published: October 18, 2022

Abstract

Background: Cadmium (Cd) is widespread pollutant that affected human health.

Objective: The present study aimed to investigate the possible protective effect of Garlic (Allium sativum) against hepatorenal toxic- ity of cadmium in rats.

Methods: 32 adult male rats were used and divided equally into four groups each with 8 rat: Group I: Control group, the rats of this group were given normal diet and water for four weeks, Group II: Garlic group, the rats of this group received garlic extract 350 mg/ kg bw by stomach tube every second day for four weeks, Group III: Cadmium group, the rat of this group received 60 mg/kg bw Cad- mium by stomach tube every second day for four weeks, and Group IV: Garlic + Cadmium group, the rat of this group received garlic extract 350 mg/kg bw then 60 mg/kg bw Cadmium by stomach tube every second day for four weeks. At the end of the experiment, samples of blood were taken for biochemical analysis. Then rats were sacrificed and dissected, and samples of liver and kidney were collected for histological studies. Body weight was measured at the beginning and the end of the experiment. Blood samples were collected at experiment end. Sera prepared to measure activities of liver and kidney functions.

Results: It was observed that weight gain was significantly decreased in Cd group and Garlic + Cd group versus control and Garlic groups. Percentage changes in body weight were significantly decreased in Cd group and Garlic + Cd group versus control and Garlic groups. Cadmium administration caused significant increases in the activities of ALT, AST and ALP enzymes, and in the values of CRE, URE, UA, TG, CHOL, LDL-c and VLDL-c, but HDL-c was significantly decreased. These changes were ameliorated with administration of garlic.

Conclusions: Cadmium administration produces toxic effects that partially improved after garlic administration due to its antioxi- dant and anti-inflammatory effects.

Keywords: Cadmium; Garlic; Liver; Kidney; Protective Effects; Physiology; Histology

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Citation

Citation: Noura Mohammed Almaimouni., et al. “Study on the Efficacy of Garlic Extract Against Cadmium Toxicity of Liver and Kidney in Rats". Acta Scientific Veterinary Sciences 4.11 (2022): 94-106.

Copyright

Copyright: © 2022 Noura Mohammed Almaimouni., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.