Osho IB, Arogbodo JO* and Faluyi OB

Department of Animal Production and Health, Federal University of Technology, Akure, Nigeria

*Corresponding Author:Arogbodo JO, Department of Animal Production and Health, Federal University of Technology, Akure, Nigeria.

Received: September 01, 2022; Published: September 18, 2022

Abstract

This study examined the therapeutic and histomorphological efficacy of ethanol leaf extract of C. albidum (G. Don) on broiler chickens infected with Salmonella enterica serovar Gallinarum (Gr. D1-1, 9, 12). A total of 108-day old broiler chickens were brooded and allotted into a clinical trial at three weeks old involving six treatments (T1 - T6) replicated thrice with six birds per replicate in a completely randomised design (CRD). T1: Infected birds but not treated (negative control). T2: Infected and treated with standard drug (gentamicin®) which served as the positive control; T3: Not infected and not treated. T4 - T6 were infected and given 100, 250 and 625 mg/kg/day of extract respectively. After the clinical trial, antimicrobial efficacy index of bacterial count was established. Analysed results showed that the therapeutic index was high as depicted in observed results of reduced level of bacterial load count in organs and samples in the different experimental set up. Significant difference (p < 0.05) occurred among post infection, post therapy and controls. Histomorphological examination of the liver and kidney of the experimental birds did not show any significant abnormal presentation. It was concluded that ethanolic leaf extract of C. albidum demonstrated highly significant therapeutic effect without any toxic influence on the vital organs and comparable to conventional antibiotic against Salmonella gallinarum which could be further explored as novel herbal antibiotic formulation against fowl typhoid.

Keywords: Antibiotic Resistance; Leaf Extract; S. Gallinarum; C. Albidum

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Citation

Citation: Osho IB., et al. “Histomorphological and Therapeutic Evaluation of Chrysophyllum Albidum (G. Don) Leaf Extract in Broiler Chickens Infected with Salmonella Gallinarum". Acta Scientific Veterinary Sciences 4.10 (2022): 00-00.

Copyright

Copyright: © 2022 Osho IB., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.