Supriya Yadav¹*, Shivendra K Dixit¹, Ujjwal K DE¹, Suhas KS² and Pankaj K Patel²

¹Department of Veterinary Medicine, Indian Veterinary Research Institute, India
²Department of Veterinary Pharmacology and Toxicology, Indian Veterinary Research Institute, India

*Corresponding Author: Supriya Yadav, Department of Veterinary Medicine, Indian Veterinary Research Institute, India.

Received: June 10, 2022; Published: June 27, 2022

Abstract

Ficus racemosa is an important medicinal plant found ubiquitously. The immunomodulatory potential of this plant has not been delved much. In the present study, we evaluated the in vivo antioxidant potential of Ficus racemosa in paraquat-induced oxidative stress in Wistar rats. The ethanolic extract of the leaves of F. racemosa was used for the study. For the in vivo study, 5 groups of 6 rats per group, including paraquat-induced oxidative stress were evaluated for responses in a 30-day experimental trial using doses of 250 mg/kg b wt. for F. racemosa extract. Oxidative stress induced by Paraquat caused an increase in ROS, caused severe liver damage, increased lipid peroxidation but not many hematological alterations. Group using F. racemosa extract and combination of Ficus extract and vitamin C showed significantly proficient results by decreasing the LPO production and helped in recovering the liver alterations.

However, further research is needed to identify the different molecular mechanisms involved in mediating the antioxidant response.

Keywords: Ficus Extract; Antioxidant; Lipid Peroxidation; Superoxide Dismutase

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Citation

Citation: Supriya Yadav., et al. “Ficus Racemose Extract and Vitamin C Ameliorate Paraquat-Induced Oxidative Stress in Wistar Rats". Acta Scientific Veterinary Sciences 4.7 (2022): 00-00.

Copyright

Copyright: © 2022 Supriya Yadav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.