Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Opinion Volume 4 Issue 7

Milk-Derived Stem Cells for Cancer Therapy

Shanti Choudhary*

College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India

*Corresponding Author: Shanti Choudhary, College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India.

Received: June 01, 2022; Published: June 27, 2022

Abstract

Milk consists of not only the nutritional components (carbohydrates, proteins, fats, vitamins, and minerals) but also the non-cellular (immunoglobulins, cytokines, and antimicrobials) and cellular (inflammatory cells, lactocytes, and stem cells) components. Nutritional components of milk provide growth and development for young ones and humans. Though the value of non-cellular components of milk is appreciated, the presence of its cellular component, stem cells in milk, is enigmatic. The evidence of stem cells in human milk was first reported by the team of Cregan and Hartman in the year 2007 [1]. Later the presence of stem cells in milk have been reported in human [2,3], murine [4], and bovine [5]. The mixture of human milk-derived cells was hematopoietic (CD34+, CD133+, and CD123+), mesenchymal (CD90+, CD44+, CD271+, and CD146+) [6], endothelial progenitors (CD105+), lactocyte (CD18+), myoepithelial (CK14/SMA+), and embryonic stem-like cells (OCT4+, SOX2+, NANOG+, and TRA 60-1+) [3]. An initial report of cow milk showed the presence of stem cell-like cells and progenitor cells. The study showed a subset (30-40%) of bovine milk-derived cells were mesenchymal (CD90+, CD73+, and CD105+) and pluripotent (SOX2+ and OCT4+) [5], though the nature of milk-derived stem cells (mdSC) to be mesenchymal remained inconclusive [3]. The recent discovery of the integration of mdSC with the brain of suckling mice pup [4] is intriguing and thus warrants further investigations. Identification and characterization of mdSC in dairy animals (cow and goat) in infancy may have a potential for future therapeutic applications like cell growth, tissue regeneration, angiogenesis and tumor suppression. In addition, the presence of stem cells in milk can be an important source for other therapeutic purposes [7,8]. The use of mdSC is advantageous not only because of the cheapest source of stem cell isolation but also due to the non-invasive method, easy to harvest, devoid of tissue rejection and free from

References

  1. Cregan MD., et al. “Identification of nestin-positive putative mammary stem cells in human breastmilk”. Cell and Tissue Research 329 (2007): 129-136.
  2. Hassiotou F., et al. “Expression of the Pluripotency Transcription Factor OCT4 in the Normal and Aberrant Mammary Gland”. Front Oncol 3 (2013): 79.
  3. Hassiotou F., et al. “Breastmilk is a novel source of stem cells with multilineage differentiation potential”. Stem Cells 30 (2012): 2164-2174.
  4. Aydın MŞ., et al. “Transfer and Integration of Breast Milk Stem Cells to the Brain of Suckling Pups”. Scientific Reports 8 (2018): 14289.
  5. Pipino C., et al. “Identification and Characterization of a Stem Cell-Like Population in Bovine Milk: A Potential New Source for Regenerative Medicine in Veterinary”. Stem Cells and Development 27 (2018): 1587-1597.
  6. Sani M., et al. “Origins of the breast milk-derived cells; an endeavor to find the cell sources”. Cell Biology International 39 (2015): 611-618.
  7. Lloyd-Lewis B., et al. “Mammary Stem Cells: Premise, Properties, and Perspectives”. Trends in Cell Biology 27 (2017): 556-567.
  8. Seldin L., et al. “Epithelial plasticity in the mammary gland”. Current Opinion in Cell Biology 49 (2017): 59-63.
  9. Rise of breast cancer in India (2020).
  10. Sharma DC. “Cancer data in India show new patterns”. The Lancet Oncology 17 (2016): e272.
  11. Vakhshiteh F., et al. “Mesenchymal stem cell exosomes: a two-edged sword in cancer therapy”. International Journal of Nanomedicine 14 (2019): 2847.
  12. Chu D-T., et al. “Recent Progress of Stem Cell Therapy in Cancer Treatment: Molecular Mechanisms and Potential Applications”. Cells (2020): 9.
  13. Toh WS., et al. “Advances in mesenchymal stem cell-based strategies for cartilage repair and regeneration”. Stem Cell Reviews and Reports 10 (2014): 686-696.
  14. Ledet MM., et al. “The secretome from bovine mammosphere-derived cells (MDC) promotes angiogenesis, epithelial cell migration, and contains factors associated with defense and immunity”. Scientific Reports 8 (2018): 5378.
  15. Beer L., et al. “Cell secretome based drug substances in regenerative medicine: when regulatory affairs meet basic science”. Annals of Translational Medicine (2017) 5:170.
  16. Morrison CD., et al. “c-Abl inhibits breast cancer tumorigenesis through reactivation of p53-mediated p21 expression”. Oncotarget 7 (2016): 72777-72794.
  17. Ganta C., et al. “Rat Umbilical Cord Stem Cells Completely Abolish Rat Mammary Carcinomas with No Evidence of Metastasis or Recurrence 100 Days Post-Tumor Cell Inoculation”. Cancer Research 69 (2009): 1815-1820.
  18. Liu K., et al. “Evaluating cell lines as models for metastatic breast cancer through integrative analysis of genomic data”. Nature Communications 10 (2019): 2138.

Citation

Citation: Shanti Choudhary. “Milk-Derived Stem Cells for Cancer Therapy". Acta Scientific Veterinary Sciences 4.7 (2022): 00-00.

Copyright

Copyright: © 2022 Shanti Choudhary. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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