College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India
*Corresponding Author: Shanti Choudhary, College of Animal Biotechnology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India.
Received: June 01, 2022; Published: June 27, 2022
Milk consists of not only the nutritional components (carbohydrates, proteins, fats, vitamins, and minerals) but also the non-cellular (immunoglobulins, cytokines, and antimicrobials) and cellular (inflammatory cells, lactocytes, and stem cells) components. Nutritional components of milk provide growth and development for young ones and humans. Though the value of non-cellular components of milk is appreciated, the presence of its cellular component, stem cells in milk, is enigmatic. The evidence of stem cells in human milk was first reported by the team of Cregan and Hartman in the year 2007 . Later the presence of stem cells in milk have been reported in human [2,3], murine , and bovine . The mixture of human milk-derived cells was hematopoietic (CD34+, CD133+, and CD123+), mesenchymal (CD90+, CD44+, CD271+, and CD146+) , endothelial progenitors (CD105+), lactocyte (CD18+), myoepithelial (CK14/SMA+), and embryonic stem-like cells (OCT4+, SOX2+, NANOG+, and TRA 60-1+) . An initial report of cow milk showed the presence of stem cell-like cells and progenitor cells. The study showed a subset (30-40%) of bovine milk-derived cells were mesenchymal (CD90+, CD73+, and CD105+) and pluripotent (SOX2+ and OCT4+) , though the nature of milk-derived stem cells (mdSC) to be mesenchymal remained inconclusive . The recent discovery of the integration of mdSC with the brain of suckling mice pup  is intriguing and thus warrants further investigations. Identification and characterization of mdSC in dairy animals (cow and goat) in infancy may have a potential for future therapeutic applications like cell growth, tissue regeneration, angiogenesis and tumor suppression. In addition, the presence of stem cells in milk can be an important source for other therapeutic purposes [7,8]. The use of mdSC is advantageous not only because of the cheapest source of stem cell isolation but also due to the non-invasive method, easy to harvest, devoid of tissue rejection and free from
Citation: Shanti Choudhary. “Milk-Derived Stem Cells for Cancer Therapy". Acta Scientific Veterinary Sciences 4.7 (2022): 00-00.
Copyright: © 2022 Shanti Choudhary. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.