Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Review Article Volume 4 Issue 7

A1 and A2 Milk, Whether to Consume or Not?

Bagavan Reddy1* and Athidi Lokavya Reddy2

1Ph.D. Scholar, Division of Animal Nutrition, Indian Veterinary Research Institute, Bareilly, India
2Senior Research Fellow, ET-IVF Lab, College of Veterinary Sciences, Korutla, P. V. Narsimha Rao Telangana State Veterinary University, Hyderabad, India

*Corresponding Author: Bagavan Reddy, Ph.D. Scholar, Division of Animal Nutrition Division, Indian Veterinary Research Institute, Bareilly, India.

Received: May 26, 2022; Published: June 15, 2022


An increase in metabolic diseases globally associated with changing lifestyles mandates continuous research on the food we consume. Though many of the conditions are multifactorial, identifying those risk factors poses a real challenge. One such risk factor currently in limelight is the myth and facts revolving around milk consumption. Milk and dairy products are said to be one of the most common essential commodities relished by people irrespective of age. But there always exists many misconceptions considering milk consumption among both literate and ignorant sectors. Observational, epidemiological, and clinical studies in humans and laboratory animals revealed potential health hazards concerned with the intake of A1 milk. However, such harmful effects are minimal with that of A2 milk. On the other hand, profound health benefits and medicinal importance were believed to be encrypted behind the consumption of indigenous dairy products. Irrespective of all these discussions conclusions on milk consumption is yet to be established. Hence, considering existing facts and beliefs, studies should be encouraged, and efforts are to be streamlined in the conservation and propagation of our indigenous breeds which are the prime source of A2 milk. This review summarised the importance of A2 milk in comparison with that of A1 milk and emphasized the necessity of protecting our natural resources within our Indian subcontinent.

Keywords: A1 Milk; A2 Milk; Epidemiological; Health Hazards


  1. Baldi A., et al. “Biological effects of milk proteins and their peptides with emphasis on those related to the gastrointestinal ecosystem”. Journal of Dairy ResearchS1 (2005): 66-72.
  2. Brooks JG. “Apnea of infancy and sudden infant death syndrome”. American Journal of Diseases of Children11 (1982): 1012-1023.
  3. Chia JSJ., et al. “A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes”. Nutrition and Diabetes5 (2017): e274-e274.
  4. Chitra P. “Bovine Milk: A1 and A2 Beta Casein Milk Proteins and their Impact on Human Health: A Review”. Agricultural Reviews (2020).
  5. Costello RB., et al. “Perspective: Characterization of Dietary Supplements Containing Calcium and Magnesium and Their Respective Ratio-Is a Rising Ratio a Cause for Concern?” Advances in Nutrition2 (2021): 291-297.
  6. De S., et al. “Indian Breed Cow Milk Powerhouse of Health”. FnBNews, Mumbai (2015).
  7. Elliott RB., et al. “Type I (insulin-dependent) diabetes mellitus and cow milk: casein variant consumption”. Diabetologia 3 (1999): 292-296.
  8. Francis FJ and Smith VL. “The effect of milk-based foliar sprays on yield components of field pumpkins with powdery mildew”. Crop Protection4 (2007): 657- 663.
  9. Knivsberg AM., et al. “A randomised, controlled study of dietary intervention in autistic syndromes”. Nutritional Neuroscience4 (2002): 251-261.
  10. Kost NV., et al. “β-Casomorphins-7 in infants on different type of feeding and different levels of psychomotor development”. Peptides 10 (2009): 1854-1860.
  11. Hamosh M., et al. “β-Casomorphins-milk β-casein-derived opioid peptides”. Textbook of gastroenterology and nutrition in infancy (1989): 143-150.
  12. H Tomkin G and Owens D. “LDL as a cause of atherosclerosiss”. The Open Atherosclerosis and Thrombosis Journal1 (2012).
  13. Hindustan Times. “Eye on immense potential. Uttarakhand plans to distil Badri cow urine, sell it to pharma firms”. Published from Dehradun on (2018).
  14. Ho S., et al. “Comparative effects of A1 versus A2 beta-casein on gastrointestinal measures: a blinded randomised cross-over pilot study”. European Journal of Clinical Nutrition9 (2014): 994-1000.
  15. Kamiński S., et al. “Polymorphism of bovine beta-casein and its potential effect on human health”. Journal of Applied Genetics3 (2007): 189-198.
  16. Kaskous S. “A1-and A2-Milk and their effect on human health”. Journal of Food Engineering and Technology 1 (2020): 15-21.
  17. Kohil A., et al. “The interplay between diet and the epigenome in the pathogenesis of type-1 diabetes”. Frontiers in Nutrition (2021): 370.
  18. Laugesen M and Elliott R. “Ischaemic heart disease, type 1 diabetes, and cow milk A1 beta-casein”. The New Zealand Medical Journal (Online)1168 (2003).
  19. Mallepalli S., et al. “Difference between A1 and A2 milk: Risk of A1 milk”. International Journal of Allied Medical Sciences and Clinical Research1 (2017): 163-167.
  20. McLachlan CNS. “β-casein A1, ischaemic heart disease mortality, and other illnesses”. Medical Hypotheses2 (2001): 262-272.
  21. National Livestock census. Department of Animal Husbandry and Dairying (2019).
  22. Nguyen DD., et al. “Formation and degradation of beta-casomorphins in dairy processing”. Critical Reviews in Food Science and Nutrition14 (2015): 1955-1967.
  23. Pal S., et al. “Milk intolerance, beta-casein and lactose”. Nutrients9 (2015): 7285-7297.
  24. Pophaly SD., et al. “Effect of Milk and Dairy Products in Colorectal Cancer”. In Colon Cancer Diagnosis and Therapy 3 (2022): 325-337.
  25. Priyadarshini P., et al. “Impact of milk protein on human health: A1 verses A2”. International Journal of Chemical Studies1 (2018): 531-535.
  26. Provot C., et al. “Complete nucleotide sequence of ovine β-casein cDNA: Inter-species comparison”. Biochimie7 (1989): 827-832.
  27. Rewers M and Ludvigsson J. “Environmental risk factors for type 1 diabetes”. The Lancet10035 (2016): 2340-2348.
  28. Sokolov O., et al. “Autistic children display elevated urine levels of bovine casomorphin-7 immunoreactivity”. Peptides 56 (2014): 68-71.
  29. Sowrirajan M. “Padhartha Gunapadam (Tamil)”. Thanjavur Maharaja Sarabojiy in Saraswati Mahal Noolagam, Thanjavur (2006): 67
  30. Shashank CG., et al. “A1 and A2 beta casein: Twin faces of milk”. Journal of Pharmacognosy and Phytochemistry 4 (2018): 221-224.
  31. Sun Z and Cade JR. “A peptide found in schizophrenia and autism causes behavioral changes in rats”. Autism1 (1999): 85-95.
  32. Sun Z., et al. “Relation of β-casomorphin to apnea in sudden infant death syndrome”. Peptides 6 (2003): 937-943.
  33. Tailford KA., et al. “A casein variant in cow's milk is atherogenic”. Atherosclerosis 1 (2003): 13-19.
  34. Truswell AS. “The A2 milk case: a critical review”. European Journal of Clinical Nutrition 5 (2005): 623-631.
  35. Teschemacher H. “Opioid receptor ligands derived from food proteins”. Current Pharmaceutical Design 9 (2003): 1331-1344.
  36. Venn BJ., et al. “A comparison of the effects of A1 and A2 β-casein protein variants on blood cholesterol concentrations in New Zealand adults”. Atherosclerosis 1 (2006): 175-178.
  37. Virtanen SM., et al. “Early introduction of dairy products associated with increased risk of IDDM in Finnish children”. Diabetes12 (1993): 1786-1790.
  38. Wada Y and Lönnerdal B. “Bioactive peptides released by in vitro digestion of standard and hydrolyzed infant formulas”. Peptides 73 (2015): 101-105.
  39. Wasilewska J., et al. “The exogenous opioid peptides and DPPIV serum activity in infants with apnoea expressed as apparent life-threatening events (ALTE)”. Neuropeptides 3 (2011): 189-195.
  40. Ul Haq MR., et al. “Impact of milk derived β-casomorphins on physiological functions and trends in research: a review”. International Journal of Food Properties8 (2014): 1726-1741.
  41. Yu X., et al. “Foam cells in atherosclerosis”. Clinica chimica acta 424 (2013): 245-252.
  42. Zeng L., et al. “Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease-accelerated atherosclerosis”. Journal of Biological Chemistry19 (2018): 7238-7249.
  43. Zoghbi S., et al. “β-Casomorphin-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway”. American Journal of Physiology-Gastrointestinal and Liver Physiology6 (2006): G1105-G1113.


Citation: Bagavan Reddy and Athidi Lokavya Reddy. “A1 and A2 Milk, Whether to Consume or Not?". Acta Scientific Veterinary Sciences 4.7 (2022): 54-60.


Copyright: © 2022 Bagavan Reddy and Athidi Lokavya Reddy. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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