Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Research Article Volume 4 Issue 4

The Efficacy of Some Fasciolicides Against Liver Fluke Infection in Cattle

Ahmed Abdel-Rady1*, Saber Kotb2, Safaa S Malek3 and Asmaa Sayed4

1,3Department of Animal medicine (Infectious Diseases), Faculty of Veterinary Medicine, Assiut University, Egypt
2Department of of Animal & Poultry Hygiene & Environmental Sanitation, Faculty of Veterinary Medicine, Assiut University, Egypt
4Field Practioner

*Corresponding Author:Ahmed Abdel-Rady, Department of Animal Medicine (Infectious Diseases), Faculty of Veterinary Medicine, Assiut University, Egypt.

Received: February 16, 2022; Published: March 28, 2022


This study aimed to detection of the efficacy of some drugs used in the field for treatment of liver fluke infection in the cattle (Bos taurus) in Egypt. Treatment trials used for three groups of naturally infected animals (positive by coprological examination) with some anthelmintic drugs differ in their chemical groups (Ivomec super, Rafoxanide, and Triclabendazole) divided into three groups 10 animals in each one. The dose was repeated twice with 3 weeks in between. Animals were examined clinically and laboratory; also fecal samples were collected and examined microscopically each time for follow-up. Egg counting using (Modified Stoll's dilution technique) was done 3 times in each group (day 1, after 3 weeks post-treatment, 6 weeks post-treatment). The efficacy of the drug is measured by improved clinical state or reduction/ disappearance of Fasciola egg count. In group I (treated by Ivomec super): Egg per gram (EPG) before treatment was 800 egg/ gram and after treatment was 1280 egg/gram, Egg reduction rate (ERR) of Ivomec super was %-60. In group II (treated by Triclabendazole): EPG before treatment was 500 egg/ gram and after treatment was 80 egg/gram, ERR of Triclabendazole was 84%. In group III (treated by Rafoxanide): EPG before treatment was 480 egg/ gram and after treatment was 160 egg/ gram, ERR of Rafoxanide was 66.6%. The anthelmintic drug wasn’t effective in the treatment of Fascioliasis as no progress in the clinical status of the infected animals and the ERR was less than 90%. Our study concluded that the ERR (egg reduction rate) of used anthelmintic drugs (Ivomec super, Triclabendazole, Rafoxanide) was less than the lower limit of the effective fasciolicides drug and the drugs wasn’t effective in treatment of fascioliasis.

Keywords: Anthelmintics; Cattle; Fasciola, Ivomec Super; Rafoxanide; Triclabendazole


  1. Ali TS., et al. "Prevalence of liver flukes infections in slaughtered animals in Kashan, Isfahan province, central Iran". The IIOAB Journal 5 (2011): 14-18.
  2. McLeod A. "World livestock 2011-livestock in food security". Food and Agriculture Organization of the United Nations (FAO) (2011).
  3. Farghali M., et al. "Impacts of iron oxide and titanium dioxide nanoparticles on biogas production: hydrogen sulfide mitigation, process stability, and prospective challenges". Journal of Environmental Management 240 (2019): 160-167.
  4. Perry BD and Randolph TF. "Improving the assessment of the economic impact of parasitic diseases and of their control in production animals". Veterinary Parasitology3-4 (1999): 145-168.
  5. Beesley NJ., et al. "Fasciola and fasciolosis in ruminants in Europe: Identifying research needs”. Transboundary and Emerging Diseases1 (2018): 199-216.
  6. Soosaraei M., et al. "Status of fasciolosis among domestic ruminants in Iran based on abattoir data: a systematic review and meta-analysis". Annals of Parasitology1 (2000): 77-86.
  7. Molina-Hernández V., et al. "Fasciola hepatica vaccine: we may not be there yet but we’re on the right road". Veterinary Parasitology1-2 (2015): 101-111.
  8. Andrews SJ. "The life cycle of Fasciola hepatica". In: Dalton JP (edition) Fasciolosis. CABI Publishing 1 (1999): 20.
  9. Mas-Coma S., et al. "Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America”. Fasciola hepatica and lymnaeids at very high altitude; S. Mas-Coma, IR Funatsu and MD Bargues. Parasitology7 (2001): 115-127.
  10. Bargues MD., et al. "European Lymnaeidae (Mollusca: Gastropoda), intermediate hosts of trematodiases, based on nuclear ribosomal DNA ITS-2 sequences”. Infection, Genetics and Evolution2 (2001): 85-107.
  11. Esteban JG., et al. "Geographical distribution, diagnosis and treatment of human fasciolosis: a review”. Research and Reviews in Parasitology7 (1998): 13-42.
  12. Dietrich CF., et al. "Fasciolosis". Zeitschrift für Gastroenterologie04 (2015): 285-290.
  13. El-Bahy NM. "Strategic control of fasciolosis in Egypt". Review article. Submitted to the Continual Scientific Committee of Pathology. Microbiology and Parasitology1 (1998): 07-11.
  14. Elitok B., et al. "Field trial on comparative efficacy of four fasciolicides against natural liver fluke infection in cattle". Veterinary parasitology3-4 (2006): 279-285.
  15. Abdel-Rady A. "Field study on efficacy of five fasciolicides against natural liver fluke infestation in cattle and sheep". 9th Scientific congress of Egyptian Society for Cattle Diseases, 2-4 Dec. Luxor, Egypt (2007): 250-257.
  16. Kaufmann J. "Parasitic infections of domestic animals". a diagnostic manual. ILRI (aka ILCA and ILRAD) (1996).
  17. Aragaw K and Tilahun H. "Coprological study of trematode infections and associated host risk factors in cattle during the dry season in and around Bahir Dar, Northwest Ethiopia". Veterinary and Animal Science 7 (2018): 100-104.
  18. Viyanant V., et al. "A comparison of a modified Quick-Kato technique and the Stoll dilution method for field examination for Opisthorchis viverrini eggs". Journal of Helminthology3 (1983): 191-195.
  19. Wood IB., et al. "World Association for the Advancement of Veterinary Parasitology (WAAVP) of guidelines for evaluating the efficacy of anthelmintic in ruminants (bovine, ovine, caprine)". Veterinary Parasitology3 (1995): 181-213.
  20. Robles-Pérez D., et al. "The diagnosis of fasciolosis in feces of sheep by means of a PCR and its application in the detection of anthelmintic resistance in sheep flocks naturally infected". Veterinary Parasitology1-2 (2013): 277-282.
  21. Power C, et al. "Review of studies on flukicide residues in cows' milk and their transfer to dairy products". Irish Journal of Agricultural and Food Research5 (2013): 197-207.
  22. Moll L., et al. "Resistance of Fasciola hepatica against triclabendazole in cattle and sheep in the Netherlands". Veterinary Parasitology1-2 (2000): 153-158.
  23. Kamaludeen J., et al. "Lack of efficacy of triclabendazole against Fasciola hepatica is present on sheep farms in three regions of England, and Wales". Veterinary Record16 (2019): 502-510.
  24. Shokier KM., et al. "Efficacy of five anthelmintics against a natural Fasciola species infection in cattle". Beni-Suef University Journal of Basic and Applied Sciences1 (2013): 41-45.
  25. Nzalawahe J., et al. "Evaluating the effectiveness of trematocides against Fasciola gigantica and amphistomes infections in cattle, using fecal egg count reduction tests in Iringa Rural and Arumeru Districts, Tanzania". Parasites and Vectors1 (2018): 1-9.
  26. Smith MC and Sherman DM. "Goat Medicine". 2nd Wiley‑Black well Pub. NY. USA (2009): 441‑463.


Citation: Ahmed Abdel-Rady., et al. “The Efficacy of Some Fasciolicides Against Liver Fluke Infection in Cattle".Acta Scientific Veterinary Sciences 4.4 (2022): 140-144.


Copyright: © 2022 Ahmed Abdel-Rady., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.008

Indexed In

News and Events

  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30th, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue".
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US