Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Research Article Volume 4 Issue 4

Evaluation of Xylazine-Ketamine-Pentazocine Anaesthesia in the Rabbit

Cecilia Omowumi Oguntoye1*, Fatai Mobolaji Lawal2, Adeniran Adetunji1 and Saheed Abiola Abimbola1

1Department of Veterinary Surgery and Radiology, University of Ibadan, Nigeria 2Department of Veterinary Surgery and Radiology, University of Ilorin, Nigeria

*Corresponding Author: Cecilia Omowumi Oguntoye, Department of Veterinary Surgery and Radiology, University of Ibadan, Nigeria.

Received: February 25, 2022; Published: March 21, 2022


The use of ketamine drug combinations for long duration of action may be indicated in rabbits. For this purpose, the intramuscular administration of xylazine (5 mg/kg), followed 10 minutes later by ketamine (35 mg/kg) with or without pentazocine (10 mg/kg) was evaluated in 6 healthy rabbits, on the basis of selected anaesthetic indices and changes in heart rate, respiratory rate and rectal temperature over a one-hour period.

Time to loss of righting reflex by the rabbits given xylazine - ketamine-pentazocine (XKP) (1.3 ± 0.3 min) was significantly (P < 0.05) shorter than that with xylazine-ketamine (XK) (1.8 + 0.3 min). Duration of recumbency with XKP (110.2 + 5.2 min) was significantly longer than that with XK (73.9 2.9 min). Time to standing with XKP (5.3 + 11min) was not significantly (P > 0.05) different from that with XK (6.3 ± 1.3min). Mean HR ranged from 199.3 ± 6.8 to 214.8 ± 10.6 beats/ min with XKP, and from 174.8 +10.3 to 194.7 10.4 beats/ min with XK. Mean RR ranged from 18.7 ± 1.6 to 38.5 ± 6.3 breaths/min, and from 31.0 ± 2.9 to 94.5 ± 8.3 breaths/min in the XKP and XK, respectively. With XKP, mean RT ranged from 38.1 ± 0.2 to 38.4 ± 0.2 °C and from 38.2 ± 0.4° to 38.7 ± 0.3°C with XK.

The addition of pentazocine to xylazine-ketamine combination resulted in shorter induction time and longer duration of recumbency, as well as higher heart rates but lower respiratory rates which were not outside physiological limits in healthy rabbits not undergoing any clinical procedures. It was concluded that XKP combination will be useful for procedures of long duration in rabbits.

Keywords: Xylazine; Ketamine; Pentazocine; Anaesthesia; Rabbits


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Citation: Cecilia Omowumi Oguntoye., et al. “Evaluation of Xylazine-Ketamine-Pentazocine Anaesthesia in the Rabbit".Acta Scientific Veterinary Sciences 4.4 (2022): 84-87.


Copyright: © 2022 Cecilia Omowumi Oguntoye., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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