Beenu Jain*1, Anuj Tewari2 and Surender Kumar Kadian1
1Department of Veterinary Microbiology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India
2Department of Veterinary Microbiology, College of Veterinary and Animal Sciences, Govind Ballabh Pant University of Agriculture and Technology, Pantnagar, Uttarakhand, India
*Corresponding Author: Beenu Jain, Department of Veterinary Microbiology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana, India.
Received: January 13, 2021; Published: January 31, 2022
In this study, serum samples from single vaccinated and multiple vaccinated animals, against Foot-and-mouth disease (FMD) were collected from field buffaloes. Samples with titre more than 1.4 in LPBE were selected for measuring antibody avidity. The study was conducted to compare the actual status of the protective antibody generated after vaccination in single and multiple vaccinated animals. The binding affinity of these antibodies were tested using an avidity ELISA. It was found that even after multiple vaccination in some of the animals the avidity was low whereas some of the single vaccinated animals showed high avidity than the multiple vaccinated animals. We conclude that multiple vaccination with strong antibody titre may not be always a true indicator of strong protective response. Hence, regular post-vaccination monitoring of antibody avidity needs to be done where there is a high virus circulation as a measure of herd immunity.
Keywords: Avidity ELISA; Foot-and-Mouth Disease; Post-Vaccination Monitoring; Herd Immunity
Citation: Beenu Jain., et al. “Comparative Study of Antibody Avidity in Single and Multiple Vaccinated Animals Against Foot-and-Mouth Disease". Acta Scientific Veterinary Sciences 4.2 (2022): 101-104.
Copyright: © 2022 Beenu Jain., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.