Ghadigaonkar Sushma¹* and Reddy Gopala A²

¹Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad, India
²PVNR, Telangana Veterinary University, Rajendranagar, Hyderabad, India

*Corresponding Author: Sushma Ghadigaonkar, Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad, India.

Received: December 07, 2021; Published: December 29, 2021

Abstract

The present study was aimed to evaluate phytochemical analysis, In-vitro antioxidant potential, and the protective effect of Ficus religiosa leaf extract (FRLE) on 5-Fluororuacil (5-FU) induced cardiotoxicity in rats. A total of 48 animals were divided into experimental and control groups and were divided into 8 groups of 6 animals each in group throughout the course of study of 14 days. FRLE control received FRLE alone (400 mg/kg b.wt.) once daily by oral intubation for 14 days. Captopril control received Captopril alone @ 20 mg/kg b.wt/day, once daily by oral intubation for 14 days. Group 4 received 5-FU (20mg/kg b. wt) from 9^th day onward for 5 days by intraperitoneal injection. Groups 5 and 6 were administered 5-FU + FRLE, and 5-FU + Captopril, respectively as per the above schedule and dosages. Myocardial antioxidant parameters, body weight, heart weight, relative heart weigh to body weight, thickness of left ventricle wall and lipid profile were determined and also for both Light and Electron Microscopical examination. 5-Fluororuacil significantly (P<0.05) altered all the parameters in study in group 4, while the groups 5 and 6 that received FRLE, TALE and Captopril along with 5-FU revealed significant improvement in all the parameters and the values were comparable to the control groups 1 to 3.

Pre-treatment with Ficus religiosa extract and its concomitant administration with 5-FU for 14 days attenuated 5-FU induced myocardial damage and effectively reverted the abnormal structural changes near to normalcy. In conclusion, these results suggest that Ficus religiosa extract has a protective potential in ameliorating 5-FU induced cardiotoxicity and the results were comparable to those of Captopril.

Keywords: Ficus religiosa; 5-Fluororuacil; Myocardial Antioxidants; HP; TEM

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Citation

Citation: Ghadigaonkar Sushma and Reddy Gopala A. “5-FU Induced Cardiotoxicity Amelioration by Aqueous Leaf Extract of Ficus religiosa". Acta Scientific Veterinary Sciences 4.1 (2022): 179-185.

Copyright

Copyright: © 2022 Ghadigaonkar Sushma and Reddy Gopala A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.