Lesser Explored Approaches for Ovulation Induction in Cows
GN Purohit1*, Amit Kumar1, Pramod Mohta2 and Priyanka Kalani3
1Department of Veterinary Gynecology and Obstetrics, College of Veterinary and Animal Science, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India
2VUTRC, Loonkaransar, RAJUVAS, Bikaner, Rajasthan, India
3MVSc Scholar, Department of Veterinary Pathology, College of Veterinary and Animal Sciences, RAJUVAS, Bikaner, Rajasthan, India
*Corresponding Author: GN Purohit, Department of Veterinary Gynecology and Obstetrics, College of Veterinary and Animal Science, Rajasthan University of Veterinary and Animal Sciences, Bikaner, Rajasthan, India..
August 13, 2021; Published: December 10, 2021
Ovulation induction in cattle has been traditionally done using either GnRH or hCG. Some of the uncommon approaches for ovulation induction include the use of insulin, prostaglandins, anti-estrogens, anti-prolactin’s and aromatase inhibitors which are briefly described in this mini-review. Experiments mentioning the use of these agents have utilized only small numbers of animals and large clinical trials are needed to validate their clinical use.
Keywords: Ovulation; Cows; Insulin; Prostaglandins; Anti-estrogens; Anti-prolactin; Aromatase Inhibitors
- Jeengar K., et al. “Ovarian cysts in dairy cows: old and new concepts for definition, diagnosis and therapy”. Animal Reproduction2 (2014): 63-73.
- Stevenson JS., et al. “Double insemination and gonadotropin-releasing hormone treatment of repeat-breeding dairy cattle”. Journal of Dairy Science 73 (1990): 1766-1772.
- Tanabe TY., et al. “Effect of gonadotropin releasing hormone on estrus, ovulation, and ovum cleavage rates of dairy cows”. Journal of Animal Science 72 (1994): 719-724.
- Morales-Roura JS., et al. “Effect of hCG treatment at the time of insemination on luteal function and fertility in repeat-breeding Holstein cows”. Veterinaria Mexico 29 (1998): 269-272.
- De Rensis F., et al. “Inducing ovulation with hCG improves the fertility of dairy cows during the warm season”. Theriogenology9 (2008): 1077-1082.
- Wiltbank MC., et al. “Physiological classification of anovulatory conditions in cattle”. Theriogenology 57 (2002): 21-52.
- Butler WR. “Nutritional interactions with reproductive performance in dairy cattle”. Animal Reproduction Science 60-61 (2000): 449-457.
- Butler ST., et al. “Insulin increases 17b-estradiol production by the dominant follicle of the first postpartum follicle wave in dairy cows”. Reproduction 127 (2004): 537-545.
- Hackbrat KS., et al. “Effects of propylene glycol or elevated luteinizing hormone during follicle development on ovulation, fertilization, and early embryo development”. Biology of Reproduction4 (2017): 550-563.
- Purohit GN. “Recent developments in the diagnosis and therapy of repeat breeding cows and buffaloes”. CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources 3 (2008): 062.
- Maffi AS., et al. “Insulin treatment does not affect follicular development but alters granulosa cell gene expression in dairy cows”. Theriogenology 133 (2019): 79-86.
- Ramoun AA., et al. “Effect of pretreatment with insulin on the response of buffaloes with inactive ovaries to gonadotrophin-releasing hormone agonist treatment in summer”. Reproduction Fertility and Development2 (2007): 351-355.
- Meena M., et al. “Thyroidal and progesterone hormones in cows with ovarian cysts and effects of therapy with levothyroxine, KI, GnRH and progesterone or Ovsynch”. Advances in Animal and Veterinary Sciences12 (2017): 514-519.
- Lewis GS. “Steroidal regulation of uterine resistance to bacterial infection in livestock”. Reproductive Biology and Endocrinology 1 (2003): 117.
- Ginther OJ., et al. “Composition and characteristics of follicular waves during the bovine estrous cycle”. Animal Reproduction Science 20 (1989): 187-200.
- Lo´pez-Gatius F., et al. “Reproductive performance of lactating dairy cows treated with cloprostenol at the time of insemination”. Theriogenology 62 (2004): 677-689.
- Berisha B., et al. “Prostaglandins in Superovulation Induced Bovine Follicles During the Preovulatory Period and Early Corpus Luteum”. Frontiers in Endocrinology 10 (2019): 467.
- Berisha B., et al. “Hypoxia-inducible factor-1alpha and nitric oxide synthases in bovine follicles close to ovulation and early luteal angiogenesis”. Reproduction in Domestic Animals 55 (2020): 1573-1584.
- Klein-Hitpab L., et al. “Gene regulation by steroid hormone receptors”. In: Daniel H, DayanAD, Peter SE, Werner G. Hormonally Active Agents in Food: Symposium/ Deutsche Forschungsgemeinschaft. Wiley-VCH, Weinheim (1998): 338-352.
- Terakawa Nv. “A possible role of clomiphene citrate in the control of preovulatory LH surge during induction of ovulation”. Acta Endocrinologica (Copenh.) 109 (1985): 58-63.
- Dugwekar VG., et al. “Induction ofestrus in anestrus cows treated with Fertivet”. Theriogenology 23 (1980): 126.
- Purohit GN and Bishnoi BL. “Some blood biochemical studies in Rathi cows and heifers before and after induction of estrus with Fertivet”. Indian Journal of Animal Reproduction 14 (1993): 74-76.
- Ubaid-Ur-Rehman., et al. “Ovulation induction in pre-pubertal Sahiwal-Friesian cross bred heifers by the use of clomiphene citrate and hCG”. Animal Reproduction Science 3-4 (2014): 141-144.
- Pendse MD., et al. “Use of ‘Fertivet’ for the treatment of repeat breeder cows in organised herd at Aarey milk colony, Bombay”. Indian Veterinary Journal 54 (1977): 69-73.
- Thakur MS., et al. “Efficacy of fertivet (clomiphene) on cystic ovaries in crossbred Holstein Friesian and Haryana cows”. Cheiron 12 (1983): 263-264.
- Bhattacharya HK and Fazili MR. “Comparison of GnRH, HCG and Clomiphene citrate for induction of ovulation in cows”. The Blue Cross Book 25 (2010): 31-33.
- Nestler JE., et al. “Effects of metformin on spontaneous and clomiphene-induced ovulation in the polycystic ovary syndrome”. New England Journal of Medicine 338 (1998): 1876-1880.
- Velaquez EM., et al. “Metformin therapy in polycystic ovary syndrome reduces hyperinsulinemia, insulin resistance, hyperandrogenemia and systolic blood pressure, while facilitating normal menses and pregnancy”. Metabolism 43 (1994): 647-654.
- Jonathan ML., et al. “Metformin in polycystic ovary syndrome: systematic review and meta-analysis”. British Medical Journal 327 (2003): 951-963.
- López-Gatius F., et al. “Ovulation failure and double ovulation in dairy cattle: risk factors and effects”. Theriogenology5 (2005): 1298-1307.
- Hooley RD., et al. “Effect of heat stress on plasma concentrations of prolactin and luteinizing hormone in ewes”. Australian Journal of Biological Sciences2 (1979): 231-235.
- Smith VG., et al. “Bovine serum prolactin, growth hormone, cortisol and milk yield after ergocryptine”. Neuroendocrinology 15 (1974): 172-181.
- Picazo RA., et al. “Effects of bromocryptine administration during the follicular phase of the estruscycle on prolactin and gonadotrophin secretion and follicular dynamics in merino monovular ewes”. Reproduction 120 (2000): 177-186.
- Casper RF., et al. “Aromatase Inhibitors for Ovulation Induction”. The Journal of Clinical Endocrinology and Metabolism3 (2006): 760-771.
- Yapura MJ., et al. “Effects of a non-steroidal aromatase inhibitor on ovarian function in cattle”. Reproduction Fertility and Development 4 (2016): 631-640.
- Yapura J., et al. “Aromatase inhibitor treatment with an intravaginal device and its effect on pre-ovulatory ovarian follicles in a bovine model”. Reproductive Biology and Endocrinology 11 (2013): 97.
- Yapura MJ., et al. “Synchronization of ovulation in cattle with an aromatase inhibitor-based protocol”. Theriogenology8 (2016): 1382-1389.
- Yapura MJ., et al. “Aromatase inhibitors: A new approach for controlling ovarian function in cattle”. Theriogenology 112 (2018): 18-25.