Bhoj R Singh*, BS Pruthvishree, Akanksha Yadav, Ravichandran Karthikeyan, Obli R Vinodhkumar and Dharmendra K Sinha

Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar, India

*Corresponding Author: Bhoj R Singh, Head, Division of Epidemiology, ICAR-Indian Veterinary Research Institute, Izatnagar, India.

Received: July 27, 2021; Published: August 18, 2021

Abstract

The study was conducted to evaluate the antimicrobial activity of aspirin, paracetamol, flunixin meglumine, tolfenamic acid and diclofenac sodium and pheniramine maleate on 499 strains of microbes of 117 species belonging to 26 genera of Gram-negative (G-ve), nine genera of Gram-positive (G+ve) bacteria and four strains of two Candida species. A total of 92.79%, 44.09%, 54.91% and 30.26% bacterial strains were sensitive to 2.56 mg/mL aspirin, 3.2 mg/mL flunixin, 2.56 mg/mL diclofenac and 1.28 mg/mL meloxicam, respectively. For paracetamol and pheniramine maleate only one strain of Aerococcus species was sensitive at ≤ 3.2 mg/mL concentration of these drugs and none of the strains was susceptible to tolfenamic acid even at 10.28 mg/mL. The analysis indicated that G+ve bacteria had significantly lower susceptibility to aspirin (OR = 0.30; CI₉₉ = 0.12 - 0.78) but higher susceptibility to flunixin (OR = 7.22; CI₉₉ = 4.12-12.50) and diclofenac (OR = 1.91; CI₉₉ = 1.15 - 3.15) than G-ve bacteria. There was no significant difference in meloxicam susceptibility of G+ve and G-ve bacteria. The study concluded that NSAIDs and pheniramine maleate may not be used as antimicrobials in therapeutically achievable systemic concentrations of the drugs within biological safety limits of plasma concentration. However, the scope of use of NSAIDs still exists in form of non-antibiotic topical antimicrobial preparations.

Keywords: NSAIDs; Antihistaminics; Antibacterials; Antibiotics; Drug-repurposing; Alternative-antimicrobials

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Citation

Citation: Bhoj R Singh., et al. “Comparative Antimicrobial Activity of Aspirin, Paracetamol, Flunixin Meglumine, Tolfenamic Acid, Diclofenac Sodium and Pheniramine Maleate". Acta Scientific Veterinary Sciences 3.9 (2021): 30-42.

Copyright

Copyright: © 2021 Bhoj R Singh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.