Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Short Communication Volume 3 Issue 8

Antimicrobial Peptides as Potential Alternative to Antibiotics

Pallvi Slathia1 and Deepti Narang2*

1Department of Veterinary Microbiology College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Punjab, India
2Principal Scientist-Cum-Head, Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Punjab, India

*Corresponding Author: Deepti Narang, Principal Scientist-Cum-Head, Department of Veterinary Microbiology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Punjab, India.

Received: June 01, 2021; Published: July 14, 2021

Introduction

Antibiotic resistance is one of the most serious challenges to global health, so researchers are looking for new ways to fight it. Antimicrobial peptides (AMPs) are one among the widely researched alternatives to standard antibiotics [3]. Antimicrobial peptides (AMPs), also known as host defense peptides, are short, naturally occurring, typically 12-50 amino acid residues long, possess a net charge (due to an abundance of Arg and Lys residues) and have a considerable proportion of hydrophobic residues (usually 50%) which allows them to fold into amphipathic conformations. They’re found in a vast variety of life forms (microorganisms to humans), display remarkable structural and functional diversity and have broad spectrum of targeted organisms [1].

References

  1. Bahar A A and Ren D. “Antimicrobial peptides”. Pharmaceuticals (Basel)12 (2013) 1543-1575.
  2. Chen Y., et al. “Role of peptide hydrophobicity in the mechanism of action of alpha-helical antimicrobial peptides”. Antimicrobial Agents Chemotherapy4 (2007): 1398-1406.
  3. Czaplewski L., et al. “Alternatives to antibiotics-a pipeline portfolio review”. Lancet Infectious Diseases 2 (2016): 239-251.
  4. Dubos R J. “Studies on a bactericidal agent extracted from a soil bacillus: I. Preparation of the agent. Its activity in vitro”. Journal of Experimental Medicine 1 (1939): 1-10.
  5. Gupta S., et al. “Host defense peptides: An insight into the antimicrobial world”. Journal of Oral and Maxillofacial Pathology 2 (2018): 239-244.
  6. https://aps.unmc.edu/AP/main.php
  7. Kumar, et al. “Antimicrobial Peptides: Diversity, Mechanism of Action and Strategies to Improve the Activity and Biocompatibility In Vivo”. Biomolecules 8.1 (2018): 4.
  8. Lee T H., et al. “Antimicrobial Peptide Structure and Mechanism of Action: A Focus on the Role of Membrane Structure”. Current Topics in Medicinal Chemistry 1 (2016): 25-39.
  9. Wimley W C. “Describing the Mechanism of Antimicrobial Peptide Action with the Interfacial Activity Model”. ACS Chemical Biology10 (2010): 905-917.
  10. Yeaman M R and Yount N Y. “Mechanisms of Antimicrobial Peptide Action and Resistance”. Pharmacological Reviews1 (2003): 27-55.

Citation

Citation: Pallvi Slathia and Deepti Narang. “Antimicrobial Peptides as Potential Alternative to Antibiotics". Acta Scientific Veterinary Sciences 3.8 (2021): 15-17.

Copyright

Copyright: © 2021 Pallvi Slathia and Deepti Narang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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