Acta Scientific Veterinary Sciences (ISSN: 2582-3183)

Research Article Volume 4 Issue 3

Haematological Profile of Dogs, Treated with Diminazene Aceturate Alone and Diminazene Plus Oxytetracycline, Long Acting

Onyeachonam FO1*, Onyeyili PA2 and Saganuwan AS2

1Department of Veterinary Biochemistry and Animal Production, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria
2Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine Federal University of Agriculture, Makurdi, Nigeria

*Corresponding Author: Onyeachonam FO, Department of Veterinary Biochemistry and Animal Production, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria.

Received: June 08, 2021; Published: July 14, 2021

Abstract

   For haematological profile of dogs treated with Diminazene aceturate (DA) alone and those treated with DA plus Oxytetracycline long acting (Oxytet LA), fourteen apparently healthy Nigerian indigenous dogs were assigned into two groups of seven dogs each. Blood samples were collected at different time intervals post treatment: 0, 1, 3, 6, 9, 12, 24, 36 and 48 hours. Means of PCV (26.63 ± 0.81a/23.44 ± 0.69 b), Hb (9.15 ± 0.31 a/8.09 ± 0.20 b), TRBC (4.10 ± 0.16 a/3.70 ± 0.15 b), Neutrophils (78.37 ± 1.05 a/75.00 ± 0.66 b) and Eosinophils (3.19 ± 0.28 a/1.89 ± 0.16 b) were significantly (P ≤ 0.05) higher in the group treated with DA alone than in the group treated with DA and Oxytet LA but means of the immune cells, Lymphocytes (21.11 ± 0.66 a/16.96 ± 1.19b) and Monocytes (2.00 ± 0.18a/1.04 ± 0.16 b) were significantly higher (P ≤ 0.05) in the group treated with DA and Oxytet LA than in the DA-alone group.

Keywords: Haematological Profile; Diminazene Aceturate; Oxytetracycline Long Acting; Dogs

References

  1. Igado OO. “Neurometrics and neurocraniometry of Nigerian local dog (Canis lupus familiaris)”. Journal of Veterinary Anatomy 4 (2011): 99 - 109.
  2. Olayemi FO., et al. “Study on erythrocyte values of the Nigerian indigenous dog”. Folia Veterinaria 53 (2009): 65-67.
  3. Peregrine AS and Mamman M. “Pharmacology of diminazene: a review”. Acta Tropica 54 (1993): 185-203.
  4. Bywater RJ. “Veterinary Applied Pharmacology and Therapeutics”. Bailliere Tindal London, UK (1991).
  5. Waugh A., et al. “Anatomy and Physiology in Health and Illness”. (9th ed). Churchill Livingston, an imprint of Elsevier Science Limited (2001): 59-71
  6. Olafedehan CO., et al. “Effects of residual cyanide in processed cassava peal meals on haematological and biochemical indices of growing rabbits”. Proceedings of 35th Annual conference of Nigerian Society for Animal Production (2010): 212.
  7. Chang YM., et al. “Serum biochemical phenotypes in the domestic dogs”. PLoS One 11 (2016): 0149650.
  8. Aderemi FA. “Effects of replacement of wheat bran with cassava root sievate supplemented or unsupplemented with enzyme on the haematology and serum biochemistry of pullet chicks”. Tropical Animal Science Journal 7 (2004): 147-153.
  9. Doyle D William Hewson (1739-74). “The father of haematology”. British Journal of Haematology4 (2006): 375-381.
  10. Jain NC. “Essentials of Veterinary Hematology”. Lea and Febiger, Philadelphia, U.S.A (1993).
  11. Khan TA and Zafar F. “Haematological study in response to various doses of oestrogen in broiler production”. International Journal of Poultry Science 10 (2005): 748-751.
  12. Etim NN., et al. “Haematological Parameters and Factors Affecting their Values”. Agricultural Science 1 (2014): 37-47.
  13. Saror DI., et al. “The haemogram of dogs with intestinal parasites in Zaria, Nigeria”. Journal of Small Animal Practice 20 (1979): 243-247.
  14. Ariyibi AA., et al. “A Comparative Study of Some Hematology and Biochemical Parameters of Clinically Healthy Alsatian and Local Dogs”. African Journal Biomedical Research 5 (2002): 145-147.
  15. Adekola AA., et al. “Baseline Haematology and Erythrocyte Morphological Changes of Apparently Normal Dogs Raised in Ibadan, Oyo State”. Nigerian Journal of Physiological Sciences 30 (2015) 111-118.
  16. Atata JA., et al. “Baseline haematological, serum biochemical and some urine parameters in Nigerian indigenous dogs”. Savannah Veterinary Journal 1 (2018): 1-5.
  17. Wolfensohn S and Lloyd M. “Handbook of Laboratory Animal Management and Welfare”. 4th edition. Wiley- Blackwell Publishing Ltd, UK; (2013): 371.
  18. Coles EH. “Veterinary Clinical Pathology”. 1st Edition. W.B. Saunders Company Ltd. Philadelphia. London; (1980): 156-193.
  19. Esievo KAN. “Veterinary Clinical Pathology”. 1st Edition. Spectrum Books Ltd, Ibadan; (2017): pp. 143-144.
  20. Billet HH. Hb and Hematocrit in Walker HK, Hall WD, Hurst JW, edition- clinical methods: The History, physical and laboratory examination; 3rd edition: (1990). chapter 151.
  21. Feldman BF., et al. “Schalm’s Veterinary Haematology”. 5th edition, Philadelphia, PA; Lippincott Williams and wilkins (2000).
  22. Purves WK., et al. “Life: The science of Biology”. 7th edition, Sinauer Associates and W. H. Freeman. (2003): 954.
  23. Nelson RW and Couto CG. “Small Animal internal medicine”. 4th edition St louis, MO: Mosby-Elsevier. (2009).
  24. Nyakundi JN., et al. “The relationships between intestinal damage and circulating endotoxins in experimental Trypanosoma brucei brucei infections”. Parasitology 124 (2002): 589-595.
  25. Soetan KO., et al. “Preliminary studies on the haematological parameters of cockrels fedraw processed ginea corn (Sorghum bicolor)”. Proceedings of 38th Annual Conference of Nigerian Society of Animal Production (2013): 49-52.
  26. Wood RD. “White Blood Cell Disorders of Dogs”. Ontario Veterinary College, University of Guelph. MSD Manual Veterinary Manual (2017).

Citation

Citation: Onyeachonam FO., et al. “Haematological Profile of Dogs, Treated with Diminazene Aceturate Alone and Diminazene Plus Oxytetracycline, Long Acting".Acta Scientific Veterinary Sciences 4.3 (2022): 11-14.

Copyright

Copyright: © 2021 Onyeachonam FO., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate35%
Acceptance to publication20-30 days
Impact Factor1.008

Indexed In





News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US