Abstract

  Human and animal environments mutually transfer emerging and re-emerging pathogens by direct animal to human contact, co-habiting and direct contact to animal faeces resulting in the occurrence of zoonotic disease.. Antibiotic resistance contributes to prolonged and fatal cases of infection in animals and a is major risk factor for human morbidity with increasing prevalence globally. The aim of study is to establish the resistance profile of causative agents of disease in companion animals and to determine their sensitivity to Roussins black salt (RBS) as a potential antibacterial agent. Methods to determine antibiotic resistance include the Kirby disk diffusion assay and the inhibition of cell growth in the presence the test agent. All isolates showed alarmingly high levels of resistance to a variety of agents, where Pseudomonas aeruginosa was the most resistant pathogen, being only susceptible to one of the carbapenem antibiotics, doripenem. Furthermore, all Gram-negative canine isolates investigated demonstrated ESBL activity. Findings showed that test concentrations of RBS provided high levels of antibacterial activity against both Gram positive and ESBL producing Gram negative species of critical and high importance according the WHO priority pathogen list, where therapeutic antibiotics failed to do so. The findings suggest a potential of RBS to act as a potential antibacterial agent in the treatment of animal infectious disease where drug resistance is present, although further studies are warranted to elucidate its mode of action and animal biocompatibility profile.

Keywords: Companion Animal; Multidrug Resistant; Pathogenic; Toxicity; Zoonosis

References

Citation

Citation: Mary Garvey., et al. “Antibacterial Activity of Roussin's Black Salt Against Multidrug Resistant Zoonotic Pathogens Isolated from Companion Animals” Acta Scientific Veterinary Sciences 2.3 (2020): 20-28.

Copyright

Copyright: © 2020 ary Garvey., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.