Acta Scientific Pharmacology

Mini Review Volume 4 Issue 2

Let’s Talk About Steroids

Nida Tabassum Khan*

Department of Biotechnology, Faculty of Life Sciences and Informatics, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Balochistan, Pakistan

*Corresponding Author: Nida Tabassum Khan, Department of Biotechnology, Faculty of Life Sciences and Informatics, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Balochistan, Pakistan.

Received: March 01, 2023 Published: June 01, 2023

Abstract

Steroids are a group of terpenoid lipids broadly disseminated in nature that present a moderately unbending chemical conformation named gonane framed by four fused alicyclic rings. The oxidation state of the steroid core and the presence of various substitutional groups determines the specific properties/function of each steroidal molecule. Steroidal compounds assume significant role in organisms, including cell proliferation, stabilization of plasma membrane, regulation of cellular pathways etc. Steroids/steroidal intermediates are synthesised on large scale either synthetically or by means of microorganisms aided bioconversion reactions that are cost-effective and environmentally friendly.

Keywords: Cell signalling; Cortisone; Biotransformation; Sapogenins; Functionalization

References

  1. Brown JM M., et al. “Studies on biliary excretion in the rabbit II. The relationship between the chemical structure of certain natural or synthetic pentacyclic triterpenes and their icterogenic activity. Part 1: the substituents on carbon atoms 3, 17, 22 and 24”. Proceedings of the Royal Society of London. Series B. Biological Sciences969 (1963): 473-491.
  2. Yadav R., et al. “Steroid chemistry and steroid hormone action: a review”. Asian Journal of Research in Chemistry11 (2014): 964-969.
  3. Nes W D. “Biosynthesis of cholesterol and other sterols”. Chemical Reviews10 (2011): 6423-6451.
  4. Wriessnegger T and Pichler H. “Yeast metabolic engineering–targeting sterol metabolism and terpenoid formation”. Progress in Lipid Research3 (2013): 277-293.
  5. Ghosh S U M I T. “Biosynthesis of structurally diverse triterpenes in plants: the role of oxidosqualene cyclases”. In Proc. Indian Natl. Sci. Acad 82 (2016): 1189-1210.
  6. Stamati K., et al. “Evolution of oxygen utilization in multicellular organisms and implications for cell signalling in tissue engineering”. Journal of Tissue Engineering1 (2011): 2041731411432365.
  7. Sankhla M S., et al. “Ecofriendly Approach for Steroids, Terpenes, and Alkaloids-based Biosurfactant”. Biointerface Research in Applied Chemistry 13 (2022): 114.
  8. Fernández-Cabezón L., et al. “New insights on steroid biotechnology”. Frontiers in Microbiology 9 (2018): 958.
  9. de Carvalho C C. “Whole cell biocatalysts: essential workers from nature to the industry”. Microbial Biotechnology 10,2 (2017): 250-263.
  10. Sankhla M S., et al. “Ecofriendly Approach for Steroids, Terpenes, and Alkaloids-based Biosurfactant”. Biointerface Research in Applied Chemistry 13 (2022): 114.
  11. Feng J., et al. “Biotransformation enables innovations toward green synthesis of steroidal pharmaceuticals”. ChemSusChem9 (2022): e202102399.
  12. AR Salvador J., et al. “Pharmaceutical green chemistry applied to the chemical synthesis of steroid compounds”. Current Green Chemistry 2 (2015): 97-134.
  13. Rosenthal K and Lütz S. “Recent developments and challenges of biocatalytic processes in the pharmaceutical industry”. Current Opinion in Green and Sustainable Chemistry 11 (2018): 58-64.
  14. Menges N. “Green protocols for active pharmaceutical ingredients (API)”. In Handbook of Greener Synthesis of Nanomaterials and Compounds (2021): 21-40.
  15. Batth R., et al. “Biosynthesis and industrial production of androsteroids”. Plants9 (2020): 1144.
  16. Sedlaczek L and Smith LL. “Biotransformations of steroids”. Critical Reviews in Biotechnology 3 (1988): 187-236.
  17. Madyastha K M. “Novel microbial transformations of steroids”. Saponins used in Food and Agriculture (1996): 259-270.
  18. Tong W Y and Dong X. “Microbial biotransformation: recent developments on steroid drugs”. Recent Patents on Biotechnology2 (2009): 141-153.
  19. Yang YY., et al. “Testosterone-mineralizing culture enriched from swine manure: characterization of degradation pathways and microbial community composition”. Environmental Science and Technology16 (2011): 6879-6886.
  20. Wang X X., et al. “Rational development of mycobacteria cell factory for advancing the steroid biomanufacturing”. World Journal of Microbiology and Biotechnology11 (2022): 191.
  21. Gupta P and Mahajan A. “Sustainable approaches for steroid synthesis”. Environmental Chemistry Letters2 (2019): 879-895.
  22. Gu Y., et al. “Metabolic engineering strategies for de novo biosynthesis of sterols and steroids in yeast”. Bioresources and Bioprocessing1 (2021): 1-14.
  23. Gauthier C., et al. “Recent progress in the synthesis of naturally occurring triterpenoid saponins”. Mini-Reviews in Organic Chemistry4 (2009): 321-344.
  24. Cheok C Y., et al. “Extraction and quantification of saponins: A review”. Food Research International, 59 (2014): 16-40.
  25. Schmitt C., et al. “Saponins: A renewable and biodegradable surfactant from its microwave-assisted extraction to the synthesis of monodisperse lattices”. Biomacromolecules3 (2014): 856-862.
  26. Devarenne T P. “Terpenoids: higher”. eLS (2009).
  27. Donova MV and Egorova O V. “Microbial steroid transformations: current state and prospects”. Applied Microbiology and Biotechnology 94 (2012): 1423-1447.
  28. Tao BY. “Industrial applications for plant oils and lipids”. In Bioprocessing for value-added products from renewable resources (2007): 611-627.
  29. Drzyzga O. “The strengths and weaknesses of Gordonia: a review of an emerging genus with increasing biotechnological potential”. Critical Reviews in Microbiology4 (2012): 300-316.
  30. Merino E., et al. “Isolation of cholesterol-and deoxycholate-degrading bacteria from soil samples: evidence of a common pathway”. Applied Microbiology and Biotechnology 97 (2013): 891-904.
  31. Liu N., et al. “Efficient microbial synthesis of key steroidal intermediates from bio-renewable phytosterols by genetically modified Mycobacterium fortuitum strains”. Green Chemistry15 (2019): 4076-4083.
  32. Zhao A., et al. “Mycolicibacterium cell factory for the production of steroid-based drug intermediates”. Biotechnology Advances 53 (2021): 107860.
  33. Fernandes P., et al. “Microbial conversion of steroid compounds: recent developments”. Enzyme and Microbial Technology6 (2003): 688-705.
  34. Świzdor A., et al. “Microbial Baeyer–Villiger oxidation of 5α-steroids using Beauveria bassiana. A stereochemical requirement for the 11α-hydroxylation and the lactonization pathway”. Steroids 82 (2014): 44-52.
  35. Cano-Flores A., et al. “Biotransformation of Steroids Using different microorganisms”. In Chemistry and Biological Activity of Steroids (2019): 5.
  36. Kołek T., et al. “Baeyer-Villiger oxidation of DHEA, pregnenolone, and androstenedione by Penicillium lilacinum AM111”. Steroids14 (2008): 1441-1445.
  37. Carballeira J D., et al. “Microbial cells as catalysts for stereoselective red–ox reactions”. Biotechnology Advances 6 (2009): 686-714.
  38. Zhu R., et al. “Cytochrome P450 Monooxygenases Catalyse Steroid Nucleus Hydroxylation with Regio‐and Stereo‐Selectivity”. Advanced Synthesis and Catalysis16 (2022): 2701-2719.
  39. Fernández-Cabezón L., et al. “New insights on steroid biotechnology”. Frontiers in Microbiology 9 (2018): 958.
  40. Roberts S M and Wan P W. “Enzyme-catalysed Baeyer–Villiger oxidations”. Journal of Molecular Catalysis B: Enzymatic 3 (1998): 111-136.
  41. Pfeifer B A and Khosla C. “Biosynthesis of polyketides in heterologous hosts”. Microbiology and Molecular Biology Reviews1 (2001): 106-118.
  42. Moser S and Pichler H. “Identifying and engineering the ideal microbial terpenoid production host”. Applied Microbiology and Biotechnology 103 (2019): 5501-5516.
  43. Alper H and Stephanopoulos G. “Engineering for biofuels: exploiting innate microbial capacity or importing biosynthetic potential?” Nature Reviews Microbiology10 (2009): 715-723.
  44. Nielsen J and Keasling J D. “Engineering cellular metabolism”. Cell6 (2016): 1185-1197.
  45. Olesti E., et al. “From a single steroid to the steroidome: Trends and analytical challenges”. The Journal of Steroid Biochemistry and Molecular Biology 206 (2021): 105797.
  46. Bloem LM., et al. “Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas”. The Journal of Steroid Biochemistry and Molecular Biology 153 (2015): 80-92.
  47. Tang R., et al. “Efficient one-step biocatalytic multienzyme cascade strategy for direct conversion of phytosterol to C-17-hydroxylated steroids”. Applied and Environmental Microbiology24 (2021): e00321-21.
  48. Pazmiño D E T., et al. “Baeyer–Villiger monooxygenases: recent advances and future challenges”. Current Opinion in Chemical Biology2 (2010): 138-144.
  49. Calero P and Nikel P I. “Chasing bacterial chassis for metabolic engineering: a perspective review from classical to non‐traditional microorganisms”. Microbial Biotechnology1 (2019): 98-124.

Citation

Citation: Nida Tabassum Khan. “Let’s Talk About Steroids". Acta Scientific Pharmacology 4.2 (2023): 03-07.

Copyright

Copyright: © 2023 Nida Tabassum Khan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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