K Ramalingam¹*, P Karnan² and A Anbarasu³

¹Mediclone Biotech Research Centre, Chennai-48, Dr. Rai Memorial Medical centre (Cancer Treatment and Research), I.E.C Member, India
²Associate Professor, GRT College of Education, Tiruttani, India
³PG Assistant in Zoology, Government Higher Secondary School, Chithathur, Tiruvannamalai, India

*Corresponding Author: K Ramalingam, Mediclone Biotech Research Centre, Chennai-48, Dr. Rai Memorial Medical centre (Cancer Treatment and Research), I.E.C Member, India.

Received: December 28, 2022 Published: December 31, 2022

Abstract

Among the essential fatty acids the alpha linolenic acid Eicosapentaenoic acid (EPA) and Docosa-hexaenoic acid (DHA) are the highly unsaturated fatty acids of omega-3 category. Alongside these, the short chain butyric acid and Gamnalinolenic acid (GLA) and Dihomogamma linolenic acid are considered to be toxic and exert cytotoxic effects on cancer cells and modulate various cells proteins to bring apoptosis. On the contrary the linoleic acid palmitic acid arachidonic acids belonging to omega-6 category are pro-inflammatory in nature. Studies have revealed that the high omega-6 relative to omega-3 fatty acids may contribute to the cancer risk especially the breast cancer in women and prostate cancer in men. The omega-6 is thought to create a pro-inflammatory milieu interior in tissues so as to promote the carcinogenesis process. The survey on both omega-3 and omega-6 FFAs has revealed that their ratios remained as 1:20 or 1:25 in general population and 1:50 in western haplogroups in particular due to the nutritional pattern ad diets alongside augmenting factors like stress, alcohol and smoking etc. Besides these essential free fatty acids the total cholesterol represents the driving factors for more glucose absorption in cancer cells and induce the hormone responsive or driven cancers such as the prostate, breast, uterine, cervical cancers etc., Hence in our body lipid profile the omega-3, omega-6 and cholesterol constitute the good, the bad and the ugly components. Reversing the above pattern of lipid profile may prove to be a good augury of lipidomic therapy to the disease cancer.

Keywords: Carcinogenesis; Apoptosis; Omega-3; Omega-6 EFAs; Cholesterol

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Citation

Citation: K Ramalingam., et al. “Omega-3, Omega-6 EFAs and Cholesterol Good - The Bad - And the Ugly in Cancer Manifestation". Acta Scientific Pharmacology 4.1 (2023): 29-31.

Copyright

Copyright: © 2022 K Ramalingam., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.