Iornumbe JU1, Nwonu CN2*, Nwonu PC3, Arubi PO4 and Okwuasaba FK1
1Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Jos, Plateau State, Nigeria
2Neuropharmacology and Behaviour Unit, Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Benue State University, Makurdi, Nigeria
3Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
4Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Benue State University, Makurdi, Nigeria
*Corresponding Author: Nwonu CN, Neuropharmacology and Behaviour Unit, Department of Pharmacology and Therapeutics, Faculty of Basic Clinical Sciences, College of Health Sciences, Benue State University, Makurdi, Nigeria.
Received: December 07, 2022 Published: December 23, 2022
The study investigated the acute and sub-chronic effects of the n-hexane seed extract of RICOM-1013-J in biochemical and haematological parameters of mature adult female Wistar rats with an average weight of 110 g. The objective of the study was to determine the immediate, short-term and prolonged toxicological profile of the extract. Thirty-four (34) adult female rats were randomly divided into three groups (n = 8) of rats. Two animals (group I) and coded A received 0.2 ml/100 g rat of vegetable oil, and served as control. Two other animals (group II) coded B received 5 mg/kg, subcut. of the extract, a third set of animals (group III) code C was administered 20 mg/kg, subcut. The last two animals (group IV) coded D were injected with 30 mg/kg, subcut. of the extract. The same dosage regimen was administered to a different set of animals of equal number in groups II and III in pairs, and coded accordingly. SGOT, SGPT, urea, total protein, alkaline phosphatise, bilirubin and haematological assays were carried out at weeks I, IV and VIII in groups I, II and III respectively. Findings from the experiment showed no significant (P > 0.05) differences in the mean values of the biochemical parameters and haematological indices test groups relative to control. The study concluded that the n-hexane seed extract of RICOM-1013-J is relatively safe in rats when administered subcutaneously.
Keywords: Biochemical Parameters; Coded; Haematological Indices; Optical Density; Ricinus communis; RICOM-1013-J; Toxicological Profile
Citation: Nwonu CN., et al. “A Study of Acute and Sub-Chronic Subcutaneous Toxicities of N-hexane Seed Extract of Ricom-1013-J in Wistar Rats". Acta Scientific Pharmacology 4.1 (2023): 21-28.
Copyright: © 2022 Nwonu CN., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.