Chidi Chukwunenye

Clinical Laboratory Assistant at College of Medicine, University of Lagos, Nigeria

*Corresponding Author:Chidi Chukwunenye, Clinical Laboratory Assistant at College of Medicine, University of Lagos, Nigeria.

Received: October 07, 2022; Published: November 30, 2022

Abstract

Great efforts are ungoing in understanding and management of diabetes, the disease and disease related complications are increasingly unabated. In spite of the presence of known antidiabetic medicine in pharmaceutical market, remedies from medicinal plants are used with success to treat this disease. A. Difformis (Araceae) is a self- growing herbaceous plant that grows in the tropical forest and is very frequently cited as a medicinal plant used in the treatment of cough, diarrhea and diabetes in southwestern Nigeria. The aim of this study is to evaluate the hypoglycaemic effect of the hydro-ethanolic extract of the rhizome of A. Difformis.
The effect of A. Difformis (125-500 mg/kg) on blood glucose levels in normal and glucose loaded rats and STZ induced diabetic rats were determined. After 21days of sub-acute treatment, blood samples were collected from rats for lipid, biochemical and insulin profiling.
In normal rats, A. Difformis did not cause significant reduction in blood glucose. At a dose of 500mg/kg, a significant decrease in blood glucose levels was observed 60 min after glucose load. A. Difformis at 500 mg/kg administered acutely showed a signicant (p < 0.0001) decrease in blood glucose level in diabetic rats. Administered sub acutely, the extract at 500 mg/kg significantly (p < 0.0001) reduced glucose levels at day 7 with subsequent decrease at day 14 and 21.The extract did not show any significant reduction in fasting blood insulin levels and biochemical parameters when evaluated showed no significant change when compared to control.
The hypoglycaemic effects of A. difformis is by reduction of blood glucose levels through possibly combination of mechanisms. This pharmacological evaluation validate the claims and its use as an anti-diabetic medicinal plant in Nigeria.

Keywords: Antidiabetic; Hydroethanolic; Rhizome; Anchomanes Difformis; Streptozotocin

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Citation

Citation: Chidi Chukwunenye. “Antidiabetic Effects of Hydroethanolic Rhizome Extract of Anchomanes Difformis (Araceae) in Streptozotocin-Induced Diabetic Rats". Acta Scientific Pharmacology 3.12 (2022): 36-58.

Copyright

Copyright: © 2022 Chidi Chukwunenye. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.