Devinder Kumar Maheshwari* and Saara Mohammad Subhan

University College of Pharmacy, Guru Kashi University, Talwandi Sabo, Bathinda, Punjab, India

*Corresponding Author: Devinder Kumar Maheshwari, University College of Pharmacy, Guru Kashi University, Talwandi Sabo, Bathinda, Punjab, India.

Received: November 21, 2022 Published: December 21, 2022

Abstract

Abies pindrow has long tradition of use in natural based medicine system of India for the treatment of diabetes. But traditional claims for antidiabetic activity have not been validated for this plant. Thus, it was considered worthwhile to investigate plant aerial parts for antidiabetic activity. The aerial parts of plant were extracted utilizing solvents in expanding request of polarity viz., petroleum ether, chloroform, methanol, and water. The chloroform, and methanol extracts were subjected to screen in vitro antidiabetic activity using starch iodine method via inhibition of α-amylase enzyme. Among different extracts, the methanol extract showed huge antidiabetic action as compared to other tested samples whereas chloroform extract exhibit mild profile of antidiabetic potential. Our preliminary phytochemical investigations showed presence of flavonoids and phenolic compounds in the bioactive methanol extract. Further, exhaustive finding of literature suggested that a number of flavonoids and phenolic compounds are scientifically reported for antidiabetic activity. Thus, finally it can be suggested that these phenolic compounds and flavonoids might be main constituents which are responsible for antidiabetic activity of plant aerial parts. These antidiabetic compounds will be isolated from bioactive methanol extract using chromatographic techniques in future investigations.

Keywords: Abies pindrow; Antidiabetic; Flavonoids; Himalayan Fir; Phenols

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Citation

Citation: Devinder Kumar Maheshwari and Saara Mohammad Subhan. “In Vitro Evaluation of Antidiabetic Profile of Abies pindrow Aerial Parts". Acta Scientific Pharmacology 3.12 (2022): 08-12.

Copyright

Copyright: © 2022 Devinder Kumar Maheshwari and Saara Mohammad Subhan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.