Shravan Kumar Paswan¹*, Pritt Verma², Lucy Mohapatra³ and Sajal Srivastava³

¹Pharma Talk Research Foundation, Lucknow, Uttar Pradesh, India
²Department of Pharmacology, Goel Institute of Pharmacy and Pharmaceutical Sciences, Lucknow, India
³Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, Lucknow, India

*Corresponding Author: Shravan Kumar Paswan, Founder and President, Pharma Talk Research Foundation, Lucknow, Uttar Pradesh, India.

Received: May 26, 2022 Published: June 22, 2022

Introduction

Umbilical cord mesenchymal stem cells are a type of multifunctional stem cell that develops from the umbilical cord. They had a high capacity for self-renewal, a multi-directional differentiation potential, and a low immunogenicity [1]. Umbilical cord and its by-product, such as follicle and infusion, have a range of purpose in tissue rebirth [2]. The umbilical cord of the human appears to be a gifted basis of stromal cells. different spongy materials that fills the bone, haematopoietic (blood) stem cells can be collected painlessly, and have a higher rate of pluripotency. Various stem cell root scheme may well result in varying quantity and community of reproductive cell. Other umbilical cord compartments with reproductive cell populations have been discovered, including the cord inside layer, adipose tissue surrounded with a blood vessels, collagen and proteoglycans.

References

1. Shang Y., et al. “Biological Characteristics of Umbilical Cord Mesenchymal Stem Cells and Its Therapeutic Potential for Hematological Disorders”. Frontiers in Cell and Developmental Biology 9 (2021): 570179.
2. Velarde F., et al. “Use of Human Umbilical Cord and Its Byproducts in Tissue Regeneration”. Frontiers in Bioengineering and Biotechnology 8 (2020): 117.
3. Ayuzawa R., et al. “Naive uman umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo”. Cancer Letter1 (2009): 31-37.
4. Pittenger M F., et al. “Multilineage potential of adult human mesenchymal stem cells”. Science 5411 (1999): 143-147.
5. Lago G., et al. “Isolation, purification and characterization of hyaluronan from human umbilical cord residues”. Carbohydrate Polymer 62 (2005): 321-326.
6. Secund R., et al. “Isolation, expansion and characterisation of mesenchymal stem cells from human bone marrow, adipose tissue, umbilical cord blood and matrix: a comparative study”. Cytotechnology 67 (2015): 793-807.
7. Fahmy M. “Anatomy of the umbilical cord”. in Umbilicus and Umbilical Cord, ed. M. Fahmy (Berlin: Springer International Publishing) (2018): 47-56.
8. Subramanian A., et al. “Comparative characterization of cells from the various compartments of the human umbilical cord shows that the wharton’s jelly compartment provides the best source of clinically utilizable mesenchymal stem cells”. PLoS ONE 10 (2015): e0127992.
9. Troyer D L and Weiss M L. “Wharton’s jelly-derived cells are a primitive stromal cell population”. Stem Cells Dayt. Ohio 26 (2008): 591-599.
10. Bongso A and Fong CY. “The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton’s jelly of the human umbilical cord”. Stem Cell Reviews and Reports 9 (2013): 226-240.
11. Wang XY., et al. “Identification of mesenchymal stem cells in aorta-gonad-mesonephros and yolk sac of human embryos”. Blood 111 (2008): 2436-2443.
12. Taghizadeh R R., et al. “Wharton’s Jelly stem cells: future clinical applications”. Placenta 32 (2011): S311-S315.
13. Bakhtyar N., et al. “Acellular gelatinous material of human umbilical cord enhances wound healing: a candidate remedy for deficient wound healing”. Frontiers in Physiology 8 (2017): 200.
14. Kalaszczynska I and Ferdyn K. “Wharton’s jelly derived mesenchymal stem cells: future of regenerative medicine? recent findings and clinical significance”. BioMed Research International (2015): 11.
15. Ren H., et al. “Comparative analysis of human mesenchymal stem cells from umbilical cord, dental pulp, and menstrual blood as sources for cell therapy”. Stem Cells International 2016 (2016): 3516574.

Citation

Citation: Shravan Kumar Paswan., et al. “Human Umbilical Cord Mesenchymal Stem Cells: Challenges and Opportunities". Acta Scientific Pharmacology 3.7 (2022): 17-18.

Copyright

Copyright: © 2022 Shravan Kumar Paswan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.