Dental Pulp Stem Cells for Stroke Therapy - A Review
Marrimekala Vinitha1*, Saraswathi Divyateja2, Sanjay Chary Thathoji1
1Doctor of Pharmacy [Pharm-D], Samskruti College of Pharmacy Affiliated to Jawaharlal Nehru Technological University - Hyderabad (JNTUH), Hyderabad, Telangana, India
2Doctor of Pharmacy [Pharm-D], Samskruti College of Pharmacy Affiliated to Jawaharlal Nehru Technological University - Hyderabad (JNTUH), Hyderabad, Telangana, India
*Corresponding Author:Marrimekala Vinitha, Doctor of Pharmacy [Pharm-D], Samskruti College of Pharmacy Affiliated to Jawaharlal Nehru Technological University - Hyderabad (JNTUH), Hyderabad, Telangana, India.
Received:
February 10, 2022 Published: February 24, 2022
Abstract
Background: Stroke is second leading cause of death and third leading cause of disability worldwide with limited restorative treatments. People with high blood pressure, high cholesterol, diabetes and those who smoke are at higher risk. Current treatment regimens are holding limitations, hence alternative approaches are being developed. One such approach is transplantation of Dental Pulp Stem Cells. Dental pulp stem cells (DPSC’s) are the mesenchymal cells derived from a cranial neural crest which have a multipotent differentiation and self-renewal ability. Other than dental diseases, they are also useful for systemic diseases. DPSC’s have significant benefits like strong proliferation ability and can be cryopreserved without losing their differentiation capacity, easy to isolate with a less invasive procedure and also there will be no immune rejection. Due to these unique properties DPSC’s are an ideal source for Ischemic stroke. This review outlines the isolation and potential use of DPSC's.
Keywords: Stem Cells; Mesenchymal Cells; Dental Pulp Stem Cells; Ischemic Stroke
References
- T Brandt., et al. “Thrombolytic Therapy of Acute Basilar Artery Occlusion. Variables Affecting Recanalization and Outcome”. Stroke 27 (1996): 875-881.
- Mayank Goyal MD., et al. “Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke”. The New England Journal of Medicine 371 (2015): 1019-1030.
- Raul G Nogueira., et al. “Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct January 4, 2018”. The New England Journal of Medicine 378 (2018): 11-21.
- Maarten G Lansberg., et al. “Efficacy and Safety of Tissue Plasminogen Activator 3 to 4.5 Hours After Acute Ischemic Stroke: A Metaanalysis (2009).
- Koji Abe., et al. “Kawahara Stem Cell Therapy for Cerebral Ischemia: From Basic Science to Clinical Applications.
- Wai Khay Leong., et al. “Human Adult Dental Pulp Stem Cells Enhance Poststroke Functional Recovery Through Non-Neural Replacement Mechanisms (2012).
- Marco Tatullo., et al. “Dental Pulp Stem Cells: Function, Isolation and Applications in Regenerative Medicine (1899).
- S Shia., et al. “Comparison of human dental pulp and bone marrow stromal stem cells by cDNA μ array analysis”. Bone 6 (2001): 532-539.
- Maryam Raoof., et al. “A modified efficient method for dental pulp stem cell isolation”. Dental Research Journal 2 (2014): 244-250.
- Gronthos S., et al. “Postnatal human dental pulp stem cells [DPSCs] in vitro and in vivo”. Proceedings of the National Academy of Sciences of the United States of America 25 (2000): 13625-13630.
- Isolation and culture of dental pulp mesenchymal stem cells.
- P Hilkens., et al. “Effect of isolation methodology on stem cell properties and multilineage differentiation potential of human dental pulp stem cells”. Cell and Tissue Research 353 (2013): 65-78.
- Jakub Suchánek., et al. “Human Dental Pulp Stem Cells – Isolation And Long Term Cultivation”. Acta Medica 3 (2007): 195-201.
- Terry C Burns., et al. “Stem Cells for Ischemic Brain Injury: A Critical Review”. The Journal of Comparative Neurology1 (2009): 125-144.
- Masahiko Sugiyama., et al. “Dental Pulp-Derived CD31⁻/CD146⁻ Side Population Stem/Progenitor Cells Enhance Recovery of Focal Cerebral Ischemia in Rats 17-9-10 (2011): 1303-1311.
- Wai khay leong., et al. “Human Adult Dental Pulp Stem Cells Enhance Poststroke Functional Recovery Through Non-Neural Replacement Mechanisms”. Stem Cells Translational Medicine 1 (2012): 177-187.
- Maria R Gancheva., et al. “Using Dental Pulp Stem Cells for Stroke Therapy”. Frontiers in Neurology 10 (2019): 422.
- Király M., et al. “Integration of neuronally predifferentiated human dental pulp stem cells into rat brain in vivo”. Neurochemistry International 3 (2011): 371-381.
- Nosrat IV., et al. “Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the nervous system”. The European Journal of Neuroscience 9 (2004): 2388-2398.
- Laura Pierdomenico., et al. “Multipotent Mesenchymal Stem Cells with Immunosuppressive Activity Can Be Easily Isolated from Dental Pulp”. Transplantation6 (2005): 836-842.
- Qing Dong., et al. “Dental Pulp Stem Cells: Isolation, Characterization, Expansion, and Odontoblast Differentiation for Tissue Engineering Methods”. Journal of Molecular Biology 1922 (2019): 91-101.
Citation
Copyright