Dental Pulp Stem Cells for Stroke Therapy - A Review
Marrimekala Vinitha1*, Saraswathi Divyateja2, Sanjay Chary Thathoji1
1Doctor of Pharmacy [Pharm-D], Samskruti College of Pharmacy Afﬁliated to Jawaharlal Nehru Technological University - Hyderabad (JNTUH), Hyderabad, Telangana, India
2Doctor of Pharmacy [Pharm-D], Samskruti College of Pharmacy Afﬁliated to Jawaharlal Nehru Technological University - Hyderabad (JNTUH), Hyderabad, Telangana, India
*Corresponding Author:Marrimekala Vinitha, Doctor of Pharmacy [Pharm-D], Samskruti College of Pharmacy Afﬁliated to Jawaharlal Nehru Technological University - Hyderabad (JNTUH), Hyderabad, Telangana, India.
February 10, 2022 Published: February 24, 2022
Background: Stroke is second leading cause of death and third leading cause of disability worldwide with limited restorative treatments. People with high blood pressure, high cholesterol, diabetes and those who smoke are at higher risk. Current treatment regimens are holding limitations, hence alternative approaches are being developed. One such approach is transplantation of Dental Pulp Stem Cells. Dental pulp stem cells (DPSC’s) are the mesenchymal cells derived from a cranial neural crest which have a multipotent differentiation and self-renewal ability. Other than dental diseases, they are also useful for systemic diseases. DPSC’s have significant benefits like strong proliferation ability and can be cryopreserved without losing their differentiation capacity, easy to isolate with a less invasive procedure and also there will be no immune rejection. Due to these unique properties DPSC’s are an ideal source for Ischemic stroke. This review outlines the isolation and potential use of DPSC's.
Keywords: Stem Cells; Mesenchymal Cells; Dental Pulp Stem Cells; Ischemic Stroke
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