Ahmed MA Shihata* and Ahmed S Ahmed
Consultant Forensic Toxicology, Forensic Medicine Authority, Assuit, Egypt Chemical Lab, Egypt
*Corresponding Author: Ahmed MA Shihata, Consultant Forensic Toxicology, Forensic Medicine Authority, Assuit, Egypt Chemical Lab, Egypt.
Received: January 27, 2022; Published: February 17, 2022
Chloroquine (CQ) which belongs to the 4-aminoquinoline group of compounds and one of the most antimalarial. Chloroquine has been studied for the treatment and prevention of coronavirus disease 2019 (COVID-19), during treating coronavirus disease 2019 (COVID-19) some big side effects were noted. Quantification method involves a protein precipitation and liquid - liquid extraction procedure, analyses from alkaline and acidic extractions before GC/MS analysis and comparisons by two thermal program gas chromatography, first method thermal analyzing prefer than second method and alkaline is more quantified than acidic extraction.
Keywords: Chloroquine; Metabolites; Toxicity; GCMS
Citation: Ahmed MA Shihata and Ahmed S Ahmed. “Quantification of Chloroquine (Free Drug) in Liver Tissues by GC-MS". Acta Scientific Pharmacology 3.4 (2022): 16-19.
Copyright: © 2022 Ahmed MA Shihata and Ahmed S Ahmed. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.