Acta Scientific Pharmacology

Research Article Volume 3 Issue 4

Quantification of Chloroquine (Free Drug) in Liver Tissues by GC-MS

Ahmed MA Shihata* and Ahmed S Ahmed

Consultant Forensic Toxicology, Forensic Medicine Authority, Assuit, Egypt Chemical Lab, Egypt

*Corresponding Author: Ahmed MA Shihata, Consultant Forensic Toxicology, Forensic Medicine Authority, Assuit, Egypt Chemical Lab, Egypt.

Received: January 27, 2022; Published: February 17, 2022

Abstract

Chloroquine (CQ) which belongs to the 4-aminoquinoline group of compounds and one of the most antimalarial. Chloroquine has been studied for the treatment and prevention of coronavirus disease 2019 (COVID-19), during treating coronavirus disease 2019 (COVID-19) some big side effects were noted. Quantification method involves a protein precipitation and liquid - liquid extraction procedure, analyses from alkaline and acidic extractions before GC/MS analysis and comparisons by two thermal program gas chromatography, first method thermal analyzing prefer than second method and alkaline is more quantified than acidic extraction.

Keywords: Chloroquine; Metabolites; Toxicity; GCMS

References

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Citation

Citation: Ahmed MA Shihata and Ahmed S Ahmed. “Quantification of Chloroquine (Free Drug) in Liver Tissues by GC-MS". Acta Scientific Pharmacology 3.4 (2022): 16-19.

Copyright

Copyright: © 2022 Ahmed MA Shihata and Ahmed S Ahmed. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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