Acta Scientific Pharmacology

Research Article Volume 3 Issue 1

Side Effects of the Largely Used Drug Indapamide; A Study on Ants as Models

Marie-Claire Cammaerts*

Independent Researcher, Retired from the Biology of Organisms Department, University of Brussels, Belgium

*Corresponding Author: Marie-Claire Cammaerts, Independent Researcher, Retired from the Biology of Organisms Department, University of Brussels, Belgium.

Received: November 26, 2021 Published: December 31, 2021

Abstract

Indapamide is a drug used since a long time for treating patients suffering from hypertension, edema or heart problems. Its side effects have never been precisely defined though, due to its modes of action, it may have such effects. Working on ants as models, we found that effectively this drug impacted the ants’ food intake, general activity, audacity, sensory perception and social relationships. Indapamide did not affect the ants’ state of stress, cognition, learning and memorization. The ants did not adapt themselves to the side effects of indapamide and developed no dependence on its consumption. Habituation to the researched effect of the drug could not be examined in ants, and should be studied in humans. In ants, the effect of indapamide slowly decreased after weaning, according to a quadratic function of time, and fully vanished in 24 hours, what allowed approving the general daily consumption of 2.50 mg. A large individual variability seemed to exist in ants. We thus suggest to examine in humans the occurrence of the different side effects observed in ants, some potential habituation to the drug effect, and to propose, case-by-case, the best possible dosage of the drug.

Keywords: Activity; Antihypertensive Drugs; Cognition; Diuretics; Memory; Myrmica sabuleti; Social Relationships

References

  1. Lamounette B. “Anatomie et PhysIologie animals”. Hachette Bnf, Sciences (2014): 308.
  2. Russell WMS., et al. “The Principles of Humane Experimental Technique”. Johns Hopkins University (2014).
  3. Wolf FW., et al. “Invertebrate models of drug abuse”. Journal of Neurobiology 54 (2003): 161-178.
  4. Andre RG., et al. “Insect Models for Biomedical Research”. In: Woodhead AD, editor. “Non mammalian Animal Models for Biomedical Research”. Boca Raton, FL: CRC Press (1989).
  5. Passera L., et al. "Les fourmis: comportement, organisation sociale et évolution”. Les Presses Scientifiques du CNRC, Ottawa, Canada (2005) : 480.
  6. Cammaerts MC. et al. “Comparative outlook over three Myrmica species’ biotopes and foragers’ know-how”. Biologia 69 (2014): 1051-1058.
  7. Cammaerts MC., et al. “Ontogenesis of ants’ cognitive abilities (Hymenoptera, Formicidae)”. Advanced Studies in Biology 7 (2015): 335-348 + synopsis: 349-350.
  8. Cammaerts MC., et al. “Ants acquire the notion of zero through experiences”. International Journal of Biology2 (2020): 13-25.
  9. Cammaerts MC., et al. “Are ants (Hymenoptera, Formicidae) capable of self recognition?”. Journal of Sciences 7 (2015): 521-532.
  10. Cammaerts MC., et al. “Ants’numerosity ability defined in nine studies”. Journal of Biology and Life Sciences1 (2020): 121-142.
  11. Cammaerts MC., et al. “Summary of seven more studies on numerosity abilities in an ant, four of them relating to human competence”. Journal of Biology and Life Sciences2 (2020): 296-326.
  12. Cammaerts MC., et al. “Non-numerical distance and size effects in an ant”. Journal of Biology and Life Sciences2 (2020): 13-35.
  13. Cammaerts MC., et al. “Weber’s law applied to the ants’ visual perception”. Journal of Biology and Life Sciences2 (2020): 36-61.
  14. Cammaerts MC., et al. “Ethological and physiological effects of the recently most used analgesic, ibuprofen; a study on ants as models”. EC Pharmacology and Toxicology4 (2018): 251-267.
  15. Cammaerts MC., et al. “Safety of glucosamine, examined on ants as models”. MOJ Biology and Medicine4 (2018): 132-142.
  16. Cammaerts MC., et al. “Ethological and physiological effects of Sativex, a cannabis-based medicine, examined on ants as models”. Acta Scientific Pharmaceutical Sciences8 (2020): 63-84.
  17. Cammaerts MC. “Side effects of ivermectin, a drug recently used to treat humans suffering from the Covid-19 illness, a study on ants as models”. AS Pharmacology10 (2021): 40-53.
  18. Siegel S. et al. “Nonparametric statistics for the behavioural sciences”. Singapore, McGraw-Hill Book Company (1989).
  19. Cammaerts MC., et al. “An easy and cheap software-based method to assess two-dimensional trajectory parameters”. Belgian Journal of Zoology 142 (2012): 145-151.
  20. Chaffman M., et al. " A review of its pharmacodynammic properties and therapeutic efficacy in hypertension”. Drugs 28 (2012): 189-235.
  21. Bataillard A., et al. “Pharmacological properties of indapamide”. Clinical Pharmacokinetic 37 (2012): 7-12.
  22. Moore RA., et al. “Antihypertensive action of indapamide and review of pharmacology and toxicology”. Current Medical Research and Opinion1 (1977): 25-32.
  23. Campbell B., et al. “Cardiovascular protective properties of indapamide”. The American Journal of Cardiaology 17 (1990): H11-H27.
  24. Chapman MD., et al. “Hyponatraemia and hypokalaemia due to indapamide”. The Medical Journal of Australia 5 (2002): 219-221.
  25. The PROGRESS Collaborative Group. “Effects of Blood Pressure Lowering With Perindopril and Indapamide Therapy on Dementia and Cognitive Decline in Patients With Cerebrovascular Disease”. Archives of Internal Medicine 9 (2003): 1069-1075.
  26. Beckett NS. et al. “Treatment of hypertension in patients 80 years of age or older”. The New England Journal of Medicine 18 (2008): 1887-1898.
  27. Olde Engbenink RHG., et al. “Effects of thiazide-type and thiazide-like diuretics on cardiovascular events and mortality”. Hypertension 5 (2015): 1033-1040.
  28. Chalmers J., et al. “Benefit of indapamide-based treatment on mortality”. Journal of Hypertension é57 (2019).
  29. Suchard MA., et al. “Comprehensive comparative effectiveness and safety of first-line antihypertensive n drug-classes: a systematic, multinational, large-scale analysis”. The Lancet10211 (2019): 1816-1826.

Citation

Citation: Marie-Claire Cammaerts. “Side Effects of the Largely Used Drug Indapamide; A Study on Ants as Models". Acta Scientific Pharmacology 3.1 (2022): 54-66.

Copyright

Copyright: © 2022 Marie-Claire Cammaerts. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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