Acta Scientific Pharmacology

Research Article Volume 3 Issue 1

Rational Selection of Valved Holding Chambers in the Treatment of COPD or Asthma by Means of the System of Objectified Judgement Analysis

Paul Hagedoorn1, Richard Dekhuijzen2, Johan Kooistra3 and Robert Janknegt4*

1technologist Inhalation, Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, The Netherlands
2Pulmonologist, Radboud University Medical Center, Nijmegen, The Netherlands
3BENU Pharmacies, Maarssen, The Netherlands
4Hospital Pharmacist, Clinical Pharmacologist Sittard, The Netherlands

*Corresponding Author: Robert Janknegt, Hospital Pharmacist, Clinical Pharmacologist Sittard, The Netherlands.

Received: December 13, 2021 Published: December 31, 2021

Abstract

Valved inhalation chambers are important instruments to increase the available dose of pressurized metered dose inhalers, in this study inhalation chambers are compared by means of the System of Objectified Judgement Analysis (SOJA) method. The SOJA method is a model for rational drug selection. The relevant selection criteria for inhalation chambers are defined and judged by a panel of experts and each selection criterion is given a relative weight. The following inhalation chambers were included: Aerochamber, Inspirachamber, Optichamber, Volumatic and Vortex. Selection criteria were: Transparancy, Feedback system in case of too forceful inhalation, Antistatic properties, Dose delivery, Availability of mouth masks, Easy to carry, Suitability for children and inclusion in Summaries of Product Characteristics of metered dose inhalers. Aerochamber showed by far the highest score. If performed well on all selection criteria. Vortex and Optichamber also performed well. Volumatic showed the lowest score.

 

Keywords: Asthma; COPD; Valved Holding; Aerochamber

References

  1. López-Campos JL., et al. “Status of and strategies for improving adherence to COPD treatment”. International Journal of Chronic Obstructive Pulmonary Disease 14 (2019): 1503‐1515.
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  6. Hagedoorn P., et al. “A comparative analysis of changes in pMDI drug dose delivery before and after detergent coating using five antistatic valved holding chambers”. The Journal of Allergy and Clinical Immunology: In Practice 8 (2020): 1124-1125.
  7. Hagedoorn P and Grasmeijer F. “Ook antistatische voorzetkamers zijn niet één-op-een uitwisselbaar bij inhalatietherapie”. COPD and Astma Bulletin Huisartsengeneeskunde (2020): 1.
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  9. Dissanayake S., et al. “Are valved holding chambers (VHCs) nterchangeable? An in vitro evaluation of VHC equivalence”. Pulmonary Pharmacology and Therapeutics 48 (2018): 179-184.

Citation

Citation: Robert Janknegt., et al. “Rational Selection of Valved Holding Chambers in the Treatment of COPD or Asthma by Means of the System of Objectified Judgement Analysis". Acta Scientific Pharmacology 3.1 (2022): 46-53.

Copyright

Copyright: © 2022 Robert Janknegt., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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