Maged Mishel Matta¹, Tarek Abdel-Zaher Karkor², Tamer Mamdouh Abdel-Dayem², Gehad Mahmoud Khamis¹ and Eman Ibrahim Anwar¹*

¹Clinical Pharmacology, Faculty of Medicine, University of Alexandria, Egypt ¹2Obstetrics and Gynecology, Faculty of Medicine, University of Alexandria, Egypt

*Corresponding Author: Eman Ibrahim Anwar, Lecturer in Clinical Pharmacology, Faculty of Medicine, University of Alexandria, Egypt.

Received: November 15, 2021 Published: December 30, 2021

Abstract

The study was designed to evaluate the effect of nifedipine and nicorandil, used either alone or combined with coenzyme Q10 supplementation, on preeclampsia. It is a single blinded randomized controlled trial conducted on 140 patients diagnosed as severe pre-eclampsia. They were randomly assigned to four groups: Group (I) who received nifedipine, group (II) who received nicorandil, group (III) who received nifedipine + coenzyme Q10 an group (IV) who received nicorandil + coenzyme Q10. Patients were assessed before and 48 hours after drugs administration. Nifedipine and nicorandil showed significant decrease in arterial blood pressure and improvement in Doppler parameters. Moreover, both nifedipine and nicorandil significantly increased endothelial nitric oxide synthase activity and superoxide dismutase activity and decreased malondialdehyde level and platelets aggregation, with no significant difference between them. The improvement in Doppler ultrasound parameters by nifedipine and nicorandil was significantly augmented by addition of coenzyme Q10 to both drugs. Coenzyme Q10 supplementation also showed a more significant increase in the superoxide dismutase activity with a more significant decrease in the malondialdehyde level. In conclusion, Coenzyme Q10, combined with either nifedipine or nicorandil might have beneficial effects on preeclampsia by lowering the oxidative stress induced vascular remodeling.

Keywords: Preeclampsia; Nifedipine; Nicorandil; Coenzyme Q10; Oxidative Stress; Vascular Remodeling

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Citation

Citation: Eman Ibrahim Anwar., et al. “Role of Nifedipine, Nicorandil, and Coenzyme Q10 Supplementation in The Treatment of Patients with Severe Preeclampsia: A Single Blinded Randomized Controlled Trial". Acta Scientific Pharmacology 3.1 (2022): 27-35.

Copyright

Copyright: © 2022 Eman Ibrahim Anwar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.