Sindhuja Moda¹ and Pradip Majumdar²*

¹Department of Mechanical Engineering, Northern Illinois University, USA
²DSinnovtech, Inc, USA

*Corresponding Author: Pradip Majumdar, DSinnovtech, Inc, USA.

Received: September 23, 2021; Published: December 30, 2021

Abstract

Brain tumors occur in the brain with the growth of abnormal cells. Despite the advancements in medical technologies and treatments, the complex geometry of the brain impedes the treatment of tumors in the brain. A promising and efficient drug targeting to the diseased regions with limited dosage input reduces the risk of potential damage of healthy- tissue cells in the vicinity of tumor. Insertion of drug particles into the bloodstream through intravenous administration is one of the efficient treatment methods which is gaining importance. Currently, extensive research is being conducted in the areas of treating brain tumors effectively with direct administration of drug through blood. In this study a three- dimensional computational simulation model of the artery capillary network with cerebral part is developed and reconstructed using multiple CT and MRI scan images of a tumor-affected patient. The simulation model includes solution of governing equations of blood flow dynamics based on Navier-Stokes equations and mass species transport based on Lagrangian particle flow dynamics in the artery network and capillaries of the adjacent tissue-tumor regions subjected to typical cardiac cycle. Computational analysis is performed to evaluate and analyze the blood flow and drug-particle distributions around the targeted region with varying concentrations. The main objective of this study is to evaluate and optimize the effectiveness of the drug delivery to the internal targeted tumor region for different input drug parameters such as drug type, density, and dose concentrations.

Keywords: Blood Flow; Brain Tumor; Lagrangian Flow

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Citation

Citation: Sindhuja Moda and Pradip Majumdar. “CFD Analysis of Blood Flow and Drug Concentration Distribution in Tumor Affected Cerebral Artery-tissue Region".Acta Scientific Pharmacology 2.12 (2021): 03-26.

Copyright

Copyright: © 2020 Sindhuja Moda and Pradip Majumdar. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.