Acta Scientific Pharmacology

Review Article Volume 2 Issue 12

Pharmacology of Gastric Acid Suppression and Regulation: Past, Present, and Future

Abdullah Zaawari*

Intern, Clinical Pharmacy Department, KIMS Hospital, Secunderabad, India

*Corresponding Author: Abdullah Zaawari, Intern, Clinical Pharmacy Department, Kims Hospital, Secunderabad, India.

Received: November 15, 2021; Published: November 30, 2021


It has been less than two centuries since the discovery of hydrochloric acid in the stomach. The understanding of the molecular pathways enabled efficient therapeutic reduction of stomach acid secretion. The remarkable advancements in the treatment of acid-related illnesses are the result of the combined efforts of several excellent pharmacologists, basic scientists, and clinical physicians. Effective stomach acid suppression therapy has significantly improved acid-related disorder treatment and prognosis. The use of proton pump inhibitors (PPIs) in clinical practice has revolutionized the medical treatment of upper gastrointestinal disorders dramatically. PPIs are the "gold standard" treatment for acid-related disorders. However, several issues persist in the treatment of acid-related disorders, such as the management of patients who do not respond adequately to PPI therapy, more effective gastroprotection, or more potent antisecretory treatment for the eradication of Helicobacter pylori infection. New ant secretory medications are continuously being developed and investigated to give a more effective and profound inhibition of stomach acid secretion. The development of acid pump antagonists, or potassium channel acid-blocking drugs (P-CABs), has been a significant step ahead.

Keywords: Gastric Acid Suppression; H2-receptor Blocker; Proton Pump Inhibitor; Potassium-competitive acid Blocker; Acid-related Disorder; Helicobacter pylori; Gastroesophageal Reflux Disease; Gastroprotection; Safety


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Citation: Abdullah Zaawari. “Pharmacology of Gastric Acid Suppression and Regulation: Past, Present, and Future". Acta Scientific Pharmacology 2.12 (2021): 20-26.


Copyright: © 2021 Abdullah Zaawari. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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