Abeer Salih Atiya and Noha Mohammed Yahya*

Chemistry Department, College of Education for Girls, Mosul University, Mosul, Iraq

*Corresponding Author: Noha Mohammed Yahya, Assistant Professor, Chemistry Department, College of Education for Girls, Mosul University, Mosul, Iraq.

Received: August 24, 2021; Published: September 23, 2021

Abstract

  Oxygen is necessary for energy production through the electron transfer chain in living system to enable the cell to perform its physiological functions, that can produce free radicals of the type of reactive oxygen species as well as reactive nitrogen species leading to cell damage due to oxidative stress that participates in the side effects of Non-Steroidal Anti-inflammatory drugs (NSAIDs). This contradictory effect of oxygen necessitated the development of an antioxidant such as ascorbic acid to protect cell against oxidation by scavenging and inhibiting the action of free radicals. This research included study the electrochemical behavior of ascorbic acid (AA) as antioxidant, ibuprofen as NSAIDs and their interaction using square wave voltammetry technique (SWV) on the hanging mercury dropping electrode (HMDE) as working electrode, Pt-wire as an auxiliary electrode and Ag/AgCl in Sat. KCl as a reference electrode. Ascorbic acid showed an oxidation peak at 0.125 V in pH 4 of acetate buffer solution. While, Ibuprofen showed Under the same default Condition a reduction peak at 0.0755V. Optimum condition were investigated such as pH, start and end potential, deposition potential, deposition time, equilibrium time, voltage step, amplitude, frequency, the size of the mercury drop and sweep rate. In addition, the interaction between the AA and ibuprofen was evaluated by utilizing the calculation of binding constant. The interaction between Ibuprofen and Ascorbic Acid was investigated by calculating the binding constant.

Keywords: Ibuprofen; Ascorbic Acid; Square Wave Voltammetry; Electrochemical Behavior

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Citation

Citation: Abeer Salih Atiya and Noha Mohammed Yahya. “Electrochemical Behavior of Ibuprofen and Its Interaction with Ascorbic Acid Using Square Wave Voltammetry". Acta Scientific Pharmacology 2.10 (2021): 18-23.

Copyright

Copyright: © 2021 Abeer Salih Atiya and Noha Mohammed Yahya. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.