Acta Scientific Pharmacology

Review Article Volume 2 Issue 9

Immunological Landscape Diversity to Covid-19 Differential Mortality and Response - A Tenable Hypothesis

A Anbarasu1, K Ramalingam2* and P Karnan3

1Assistant Professor, Vadaranyam College of Education, Tiruvallur, India
2Mediclone Biotech Research Centre and Rai Memorial Hospital Cancer Treatment and Research, Chennai, India
3Associate Professor, GRT College of Education, Tiruttani, India

*Corresponding Author: K Ramalingam, Assistant Professor, Vadaranyam College of Education, Tiruvallur, India.

Received: August 07, 2021; Published: August 26, 2021


Consequent to the outbreak of SARS-COV1-2 virus throughout the world since 2020, the mortality or death toll was noticed in all countries. The death due to COVID-19 diseases was attributed to the adverse pathological effects of the virus on the lung alveolar cells and the endothelial cells. The death was also enhanced in morbid patients suffering, diabetic cardiac, B.P, and kidney problems. The excess secretion of inflammatory cytokines and the cytokine storms brought the above overt and covert deaths. Inspite of the potential of the virus’s infection from individuals, groups and through ambience and materials the deaths among were differential. The differential mortality and prevalence rate was marked within a single geographical province like Indian peninsular regions and in its southern state (Tamil Nadu). The meta- analysis and epidemiological comparisons of seroprevalence in different populations attribute immunological landscape diversity to the differential mortality and response. Such diversities in immunological profile do exist between individuals, populations and ethnic groups for various diseases like cancer, arthritis and other auto immune diseases. Several intrinsic and extrinsic factors are determinants to such variations, and to the susceptibility of individuals or to their resistance. Taking cue from the polymorphic potential of the SARS virus and their antigenic expressions, the present note elucidates the importance of different preventive strategies to overcome the pandemic and to curtail the exacerbating factors.

Keywords: SARS-COV-2; Immunological Landscape; Seroprevalence; Lung Cells Pathology; Immunization


  1. Singh Pooja., et al. “Role of ethenic variations in TNF-α and TNF- β Polymorphism and risk of breast cancer in India”. Breast Cancer Research and Treatment3 (2010): 739-747.
  2. Ramalingam K. “Epidemiological indices for breast cancer in south Indian population”. Global Oncology and Cancer Conference (USA) (2015).
  3. Ramalingam K. Prudent Proxies to prevent cancer -II, Phyto Therapy, K.R Spectrum Academy: Natural facts Series (2018).
  4. Indira P and Ramalingam K. “The Socio-Cultural factors behind rare incidence of cancers in Peruamal Thevanpatti (Viruthunagar District, Tamil Nadu)”. Indian Journal of Public Health Research and Development (2013).
  5. Ramalingam K., et al. “Strategic Approach in metastatic cancer Therap: Phytochemical Nutrient Adjuvants -A Mini Review”. Journal of Clinical Trials and Research1 (2019): 59-62.
  6. , et al. “Hydroxychloroquine and azithromycin plus zinc vs hydroxychloroquine and azithromycin alone: outcomes in hospitalized COVID-19 patients”. Journal of Medical Microbiology 212 (2020): 465-8834.
  7. Ramalingam K. Prudent Proxies to Prevent cancer, Natural Elixies: Wise alternatives. K.R Spectrum Academy: Natural facts Series (2017).


Citation: K Ramalingam., et al. “Immunological Landscape Diversity to Covid-19 Differential Mortality and Response - A Tenable Hypothesis".Acta Scientific Pharmacology 2.9 (2021): 20-23.


Copyright: © 2020 K Ramalingam., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Acceptance rate36%
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