Acta Scientific Pharmacology

Research Article Volume 2 Issue 7

Kinetic Study of Some Naproxen Derivatives

Nada J Abdulkareem, Noha M Yahya and Mohammad S Al-Ajely*

Chemistry Department, College of Education for Girls, Mosul University, Mosul, Iraq

*Corresponding Author: Mohammad S Al-Ajely, Chemistry Department, College of Education for Girls, Mosul University, Mosul, Iraq.

Received: June 04, 2021; Published: June 30, 2021


It was known that Salicylic acid is an analgesic compound but the presence of OH of the carboxyl group cause corrosion to the blood vessels so it was converted into ester to overcome this phenomena and becomes a pro drug. it was also known that procaine is a good anesthetic but because of its ester moiety which is easily hydrolyzed making this compound inefficient for this purposes compared to Lidocaine because Lidocaine is an amide compound which takes more time to be hydrolyzed (more stable), so it is used as analgesic instead of Procaine in locally anesthetic applications. In this study we have synthesized some esters and amide of Naproxen (Naproxen Pro drug) these compounds include P-hydroxy phenyl, Methyl, Butyl and p- amino benzoate of Naproxen which are pro drug 1, pro drug 2, 3 and pro drug 4 respectively. The results of their kinetic hydrolysis studies are discussed therein.

Keywords: Kinetic; Study; Naproxen; Derivatives


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Citation: Mohammad S Al-Ajely., et al. “Kinetic Study of Some Naproxen Derivatives".Acta Scientific Pharmacology 2.7 (2021): 39-47.


Copyright: © 2020 Mohammad S Al-Ajely., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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