Acta Scientific Pharmacology

Research Article Volume 3 Issue 10

Study of Combination the Antifungal with the Antibacterial against Bacteria Staphylococcus aureus Isolated from Skin Infection

Dhafer Rahman Abed Al-janabi*

Department of Medical Laboratory Techniques, Faculty of Medical Technologies, Islamic University, Iraq

*Corresponding Author: Dhafer Rahman Abed Al-janabi, Department of Medical Laboratory Techniques, Faculty of Medical Technologies, Islamic University, Iraq.

Received: June 07, 2021; Published: September 23, 2022


Bacteria are one of the factors that cause skin infections. Staphylococcus aureus was the most prevalent type and because of the frequent use of antibacterial, many of them have become resistant. From this principle, it is necessary to test new ones. The combination of the antifungal itraconazole with the antibacterial amoxicillin, norfloxacin and trimethoprim was tested, and some results gave a higher effect compared to the antibacterial. It is possible to use these synergies for skin infections.

Keywords: Antifungal; Antibacterial; Skin Infection; Staphylococcus aureus


  1. S K Paul., et al. “In Silico Molecular Docking Study of Delafloxacin against 4MQT for the Treatment of Acute Bacterial Skin and Skin Structure Infections”. International Journal of Advanced Biotechnology and Research 1 (2019): 144-150.
  2. DL Stulberg., et al. “Common bacterial skin infections”. American Family Physician 1 (2002): 119.
  3. PY Ong and D Y M Leung. “Bacterial and viral infections in atopic dermatitis: a comprehensive review”. Clinical Reviews in Allergy and Immunology 3 (2016): 329-337.
  4. A Pfalzgraff., et al. “Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds”. Frontiers in Pharmacology 9 (2018): 81.
  5. B P Kelly. “Superficial fungal infections”. Pediatric Review 4 (2012): e22-37.
  6. , et al. “Heterogeneities in Leishmania infantum infection: using skin parasite burdens to identify highly infectious dogs”. PLOS Neglected Tropical Diseases 8.1 (2014): e2583.
  7. K Becker., et al. “Coagulase-negative staphylococci”. Clinical Microbiology Reviews 4 (2014): 870.
  8. SJ Dancer. “Controlling hospital-acquired infection: focus on the role of the environment and new technologies for decontamination”. Clinical Microbiology Reviews 4 (2014): 665.
  9. R Reid., et al. “Pathology illustrated E-book”. Elsevier Health Sciences (2011).
  10. F W Danby. “Acne: causes and practical management”. Wiley Online Library (2015).
  11. X Wittebole., et al. “A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens”. Virulence1 (2014): 226-235.
  12. D K Byarugaba. “Mechanisms of antimicrobial resistance”. in Antimicrobial resistance in Developing Countries, Springer (2010): 15-26.
  13. J Schnürer and J Magnusson. “Antifungal lactic acid bacteria as biopreservatives”. Trends in Food Science and Technology 1-3 (2005): 70-78.
  14. K Matsui., et al. “Comparative study of Staphylococcus aureus isolated from lesional and non‐lesional skin of atopic dermatitis patients”. Microbiology and Immunology 11 (2000): 945-947.
  15. BA Forbes., et al. “Diagnostic microbiology”. Mosby St Louis (2007).
  16. JF Mac Faddin. “Biochemical tests for identification of medical bacteria”. Williams and Wilkins Co., (2000).
  17. D R A Al-janabi and E A al-R A. “Semysim”. International Journal of Research in Pharmaceutical Sciences (2020).
  18. J A Lindsay., et al. “Microarrays reveal that each of the ten dominant lineages of Staphylococcus aureus has a unique combination of surface-associated and regulatory genes”. Journal of Bacteriology 2 (2006): 669.
  19. I Brook. “Secondary bacterial infections complicating skin lesions”. Journal of Medical Microbiology 10 (2002): 808-812.
  20. B J Akhavan., et al. “Amoxicillin”. StatPearls Internet. (2020).
  21. G C Crumplin., et al. “Investigations into the mechanism of action of the antibacterial agent norfloxacin”. Journal of Antimicrobial Chemotherapy 13 (1984): 9-23.
  22. EP Quinlivan., et al. “Mechanism of the antimicrobial drug trimethoprim revisited”. FASEB Journal 15 (2000): 2519-2524.


Citation: Dhafer Rahman Abed Al-janabi. “Study of Combination the Antifungal with the Antibacterial against Bacteria Staphylococcus aureus Isolated from Skin Infection".Acta Scientific Pharmacology 3.10 (2022): 16-19.


Copyright: © 2022 Dhafer Rahman Abed Al-janabi. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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