Acta Scientific Pharmacology

Short Communication Volume 2 Issue 5

Coronavirus Disease Prevention: Opportunities and Challenges

Gundu HR Rao*

Emeritus Professor, Laboratory Medicine and Pathology, Director, Thrombosis Research, Lillehei Heart Institute, University of Minnesota, USA

*Corresponding Author: Gundu HR Rao, Emeritus Professor, Laboratory Medicine and Pathology, Director, Thrombosis Research, Lillehei Heart Institute, University of Minnesota, USA.

Received: April 14, 2021; Published: April 28, 2021

  SARS-CoV-2 the most potent killer virus, which originated from Wuhan province of China, has created an unprecedented health and economic crisis worldwide [1-3]. At the time of this writing, according to Johns Hopkins Coronavirus-tracker, (coronavirus.jhu.edu/map.html; April 8th, 2021) globally, 133 million (mil) individuals have tested positive to this virus, and over 2.9 (mil) have died. In the USA, which represents 4% of the world population, there are 31 (mil) infected individuals and over 562,360 Covid-related deaths. Little is known about the epidemiology of this disease in low- and middle-income countries. In a first of a kind review, Indo-US collaborators, conclude that, “Among 575,071 individuals exposed to 84,965 confirmed cases, infection probabilities ranged from 4.7 - 10.7% for low-risk and high-risk contact types. Case fatality ratios spanned 0.05% at ages 5 - 17 years to 16.6% at ages greater than 85 years [4,5]. According to a CNN news report, “A national (ICMR) survey of more than 29,000 people across villages and wards found, that about one in 15 people above age of 10, has antibodies against coronavirus. More than 63 million people in India, may have contracted Covid-19, according to the health authorities in India. Currently USA, India, Brazil, France, and Russia rank as the top five contenders for the highest number of COVID-positive individuals. As far as COVID-related deaths are concerned, USA, Brazil, Mexico, India, and the UK are the top five contenders. Since the time it was discovered in China to this day, the virus has mutated several times into highly transmissible and deadly strains. At the time of this writing the British, Brazilian, South African, and Indian double mutant strains are causing a havoc worldwide. Various research groups have carried out genomic sequencing of the COVID-19 virus and shared these sequences on public databases, including GISAID. Since majority of countries have done limited testing for SARS-CoV-2 virus, it is estimated that the incidence and prevalence of infection may be at least ten-fold higher than reported.

References

  1. Li Q., et al. “Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia”. The New England Journal of Medicine 382 (2020): 1199-1207.
  2. Zhou F., et al. “Clinical Course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study”. Lancet 395 (2020): 1054-1062.
  3. Guan WJ., et al. “Clinical characteristics of coronavirus 2019 in China”. The New England Journal of Medicine 382 (2020): 1708-1720.
  4. Gupta M., et al. “The need for COVID-19 research in low-and middle-income countries”. Global Health Research Policy 5 (2020): 33.
  5. Laxminarayan R., et al. “Epidemiology and transmission dynamics of COVD-19 in tow Indian States”. Science 6517 (2020): 691-697.
  6. Cyranoski D. “Profile of a killer: the complex biology powering the coronavirus pandemic”. Nature 581 (2020): 22-26.
  7. Wang M., et al. “Remedesivir and chloroquine effectively inhibit the recently emerged novel coronavirus. (2019-nCoV) in vitro”. Cell Research 30 (2020): 269-271.
  8. Liu J., et al. “Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro”. Cell Discovery 6 (2020): 16.
  9. Abella BS., et al. “Efficacy and safety of Hydroxychloroquine vs Placebo for Pre-exposure SARS-C-V-2 Prophylaxis Among Health Care Workers: A randomized Clinical Trial”. JAMA Internal Medicine (2020).
  10. Cohen MS. “Hydroxychloroquine for the prevention of Covid-19-searching for evidence”. The New England Journal of Medicine6 (2020): 585-586.
  11. Cohen J. “Designer antibodies could battle COVID-19 before vaccines arrive”. Science (2020).
  12. Wu Z and McGoogan JM. “Characteristics of and Important Lessons From the Coronavirus Disease 2109 (COVID-19) Outbreak in China. Summary Report of 72314 cases From the Chinese Center for Disease Control and Prevention”. JAMA 13 (2020): 1239-1242.
  13. McCloskey B and Heymann DL. “SARS to novel coronavirus: old lessons and new lessons”. Epidemiology Infection 148 (2020): e22.
  14. Wilder-Smith A and Freedman DO. “Isolation, social distancing, and community containment: pivotal role for old style public health measures in the novel coronavirus (2019-nCoV) outbreak”. Journal of Travel Medicine 27 (2020).
  15. Baden LR., et al. “Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine”. The New England Journal of Medicine 384 (2021): 403-416.
  16. Walsh EE., et al. “Safety and immunogenicity of two RNA-based Covid19 vaccine candidates”. The New England Journal of Medicine 383 (2020): 2439-2450.
  17. Rao GHR. “Coronavirus Disease (COVID-19) and Acute Vascular Events: Editorial”. Clinical and Applied Thrombosis/Hemostasis 26 (2020).
  18. Rao GHR. “SARS-CoV-2 biochemistry, Transmission, Clinical Manifestations and Prevention”. International Journal of Biomedicine 4 (2020): 303-311.
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Citation

Citation: Gundu HR Rao. “Coronavirus Disease Prevention: Opportunities and Challenges".Acta Scientific Pharmacology 2.5 (2021): 19-22.




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