Abstract

Objective: Applying Proniosomal Gels(PGs) in transdermal drug delivery system has evoked impressive intrigue in light of their great water-solvency and biocompatibility. The point of present investigation was to get ready and describe proniosomes of Meloxicam(MLX) for osteoarthritis. which may convey these medications to focused site more effectively than and furthermore beat the issues related with oral organization of MLX.

Methodology: Proniosomes were set up by coacervation phase separation technique at that point described for molecule size, capture effectiveness (EE), zeta potential and saturation examines. Vesicular size was controlled by optical microscopy and saw as changed from 05.61 ± 0.04 to 10.30 ± 0.05 µm relying upon the convergences of range.

Results: The normal percent of drug entrapment was in range 67.2 ± 1.44 % to 76.8 ± 0.60 %. It was seen that F3 detailing was having zeta capability of MLX was - 54.6 mV so don't aggregate quickly. The drug release of MLX was 84.21% run from 84.68%. Proniosomal gel was readied read for its discharge and physicochemical qualities.

Conclusion: At last, F3 exhibited better osteoarthritis impact to improve adequacy, steadiness and to lessen symptoms and poisonousness related with the picked drugs so as to treat Osteoarthritis.

Keywords: Meloxicam; Proniosomes; Topical Delivery; Proniosomal Gel; Irritation Studies

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Citation

Citation: Priyanka Maurya. “Development, Characterization and Transdermal Delivery of Meloxicam Entrapped in Proniosomal Gel for the Treatment of Osteoarthritis".Acta Scientific Pharmacology 2.2 (2021):.

Copyright

Copyright: © 2020 Priyanka Maurya. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.