Abstract

  Azithromycin and metal interaction and successfully found there after interaction result. Also, the antimicrobial activity of drug and the metals complexes were determined. This has been seen that the Azithromycin interacts along with metal at the pH 7.4. The different essential metal intricate of the azithromycin has been synthesized in addition to characterized by the techniques like NMR, UV, atomic absorption, FT-IR as well as elemental analysis. Spectroscopic, IR Spectroscopic, disk diffusion method, Biological assay studies of complexes. On the other hand in this interaction there uses metals complex which are interaction with drug into our body. And have been use there various type of bacteria for finding zone of inhibition. Some paper there uses methanol and ethanol for disk diffusion result clearly showing. If we use Azithromycin in a single way then it has a high bioavailability and proportionally increasing the absorption with concentration. But if we use its interaction with metals then it bioavailability and absorption decrease and less half life. By using there a various of methods and study such as Antifungal study, Antibacterial study, Biological study with different type of spectroscopic analysis, Conductrometric, IR spectrometric and Disk-diffusion methods its shows that’s less pharmacological action. So that after all discussion its concluded that if we taken Azithromycin then we will use the metals complex before two hours and after one hour. There is or will no interaction and in this we say well and get the best bioavailability and high pharmacological action.

Keywords: Azithromycin; Review; Interaction; Pharmacological Action

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Citation

Citation: Shuvo Dash and Md Shahidul Islam. “Azithromycin and Metals Complex Interaction: A Systemic Review on Drug-Metals Interaction".Acta Scientific Pharmacology 1.12 (2020): 03-05.

Copyright

Copyright: © 2020 Shuvo Dash and Md Shahidul Islam. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.