Acta Scientific Pharmacology

Research Article Volume 1 Issue 12

Azithromycin and Metals Complex Interaction: A Systemic Review on Drug-Metals Interaction

Shuvo Dash and Md Shahidul Islam*

Department of Pharmacy, University of Science and Technology Chittagong (USTC), Chattogram, Bangladesh

*Corresponding Author: Md Shahidul Islam, Assistant Professor, Department of Pharmacy, University of Science and Technology Chittagong (USTC), Chattogram, Bangladesh.

Received: September 08, 2020; Published: November 18, 2020

×

Abstract

  Azithromycin and metal interaction and successfully found there after interaction result. Also, the antimicrobial activity of drug and the metals complexes were determined. This has been seen that the Azithromycin interacts along with metal at the pH 7.4. The different essential metal intricate of the azithromycin has been synthesized in addition to characterized by the techniques like NMR, UV, atomic absorption, FT-IR as well as elemental analysis. Spectroscopic, IR Spectroscopic, disk diffusion method, Biological assay studies of complexes. On the other hand in this interaction there uses metals complex which are interaction with drug into our body. And have been use there various type of bacteria for finding zone of inhibition. Some paper there uses methanol and ethanol for disk diffusion result clearly showing. If we use Azithromycin in a single way then it has a high bioavailability and proportionally increasing the absorption with concentration. But if we use its interaction with metals then it bioavailability and absorption decrease and less half life. By using there a various of methods and study such as Antifungal study, Antibacterial study, Biological study with different type of spectroscopic analysis, Conductrometric, IR spectrometric and Disk-diffusion methods its shows that’s less pharmacological action. So that after all discussion its concluded that if we taken Azithromycin then we will use the metals complex before two hours and after one hour. There is or will no interaction and in this we say well and get the best bioavailability and high pharmacological action.

Keywords: Azithromycin; Review; Interaction; Pharmacological Action

×

References

  1. Taylor SP., et al. “Azithromycin for the Prevention of COPD Exacerbations: The Good, Bad, and Ugly”. The American Journal of Medicine 128 (2015): 1362.
  2. Rolfe RD and Finegold SM. “Comparative In Vitro Activity of Ceftriaxone Against Anaerobic Bacteria”. Antimicrobial Agents and Chemotherapy2 (1982): 338-341.
  3. Laghari M., et al. “Spectrophotometric determination of ceftriaxone using 4-dimethylaminobenzaldehyde”. Pakistan Journal of Analytical and Enviromental Chemistry1 (2008): 1-7.
  4. Izadi M., et al. “Levofloxacin Versus Ceftriaxone and Azithromycin Combination in the Treatment of Community Acquired Pneumonia in Hospitalized Patients”. Recent Patents on Anti-Infective Drug Discovery 3 (2018): 228-239.
  5. Islam SA., et al. “Bangladesh Pharmaceutical Industry: Perspective and the Prospects”. Bangladesh Journal of Medical Science4 (2018): 519-525.
  6. Corrêa JC., et al. “Randomized, open-label, parallel-group, multicenter study of the efficacy and tolerability of IV gatifloxacin with the option for oral stepdown gatifloxacin versus IV ceftriaxone with the option for oral stepdown clarithromycin”. Clinical Therapeutics5 (2003): 1453-1463.
  7. “Lack of interaction between azithromycin and carbamazepine”. In Proceedings of the British Pharmacological Society, London (1991).
  8. Ruff F., et al. “Effect of erythromycin, clarithromycin and azithromycin on the pharmacokinetics of terfenadine”. European Journal of Clinical Pharmacology 39 (1990): 165-167.
  9. Cummins LH., et al. “Theophylline determinations”. Annals of Allergy 37 (1977): 450.
×

Citation

Citation: Shuvo Dash and Md Shahidul Islam. “Azithromycin and Metals Complex Interaction: A Systemic Review on Drug-Metals Interaction".Acta Scientific Pharmacology 1.12 (2020): 03-05.




Metrics

Acceptance rate36%
Acceptance to publication20-30 days

Indexed In


News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is April 30, 2021.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US