Acta Scientific Pharmacology

Editorial Volume 1 Issue 10

The Genomic Material of CoV-19 and their Role in Pathogenesis

Sudip Kumar Mandal1*, Sipra Sarkar2and Dhrubo Jyoti Sen3

1Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, West Bengal, India
2Department of Pharmaceutical Technology, Brainware University, Barasat, Kolkata, West Bengal, India
3Department of Pharmaceutical Chemistry, School of Pharmacy, Techno India University, Salt Lake City, Kolkata, West Bengal, India

*Corresponding Author: Sudip Kumar Mandal, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy and Allied Health Sciences, Durgapur, West Bengal, India.

Received: October 28, 2020; Published: October 29, 2020

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  The 2019 novel coronavirus (CoV-19) is a dangerous virus which has caused a severe pandemic throughout the world. The covid-19 is not so much different form severe acute respiratory syndrome coronavirus (SARS-CoV) but their mode of communication is human contacts. The gnomic structure of CoV-19 possesses the largest genomes (26.4 to 31.7 kb) among all RNA virus. Two-third of their RNA has viral polymerase, RNA synthesis material and two large non-structural polyproteins that are not actually involved in host response modulation (ORF1a/ORF1b). Other one-third of the gnome encodes structural proteins such as spike (S), envelope (E), membrane (M), nucleocapsid (N) and other helper proteins. The length of their genome showed high variability for ORF1a/ORF1b and structural proteins. It is generally associated with number and size of proteins. Genomic encoding occurs after entering to the human cell and facilitates the expression of genes and encode according to useful accessory proteins with advance adaptation of the virus to their human host [1].

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Citation

Citation: Sudip Kumar Mandal., et al. “The Genomic Material of CoV-19 and their Role in Pathogenesis".Acta Scientific Pharmacology 1.12 (2020): 01-02.




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