Acta Scientific Pharmacology

Review Article Volume 1 Issue 10

Emerging Diverse Medicinal Properties of Piperine: A Review

M Ravindra Babu1*, Bhola Sai Kumar2, Bukkitla Ragini2 and AB Sravani3

1Assistant Professor, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India
2Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India
3Research Scholar, Manipal College of Pharmaceutical Sciences (MCOPS), MAHE, Manipal, Karnataka, India

*Corresponding Author: M Ravindra Babu, Assistant Professor, Sree Vidyanikethan College of Pharmacy, Tirupati, Andhra Pradesh, India.

Received: July 14, 2020; Published: September 25, 2020

×

Abstract

  Piperine is the principle alkaloid present in Piper nigrum and Piper longum species of black pepper which has wide range of pharmacological activities. Piperine was used in the preparation of traditional medicines as well as in modern medicine. Piperine was found to have many pharmacological actions such as analgesic, anti-inflammatory, antioxidant, antitumor, anti-epileptic, anti-rheumatic, hepatoprotective, immunomodulatory effects and so on, in various animal models. The piperine use has been limited due to its low aqueous solubility. For the formulation of a wide range of poorly aqueous soluble drugs, solid lipid nanoparticles are used because of their biodegradable and biocompatible properties and low toxicity. Solid lipid nanoparticles possess unique properties like small size, large surface area and high drug loading ability. The solubility of piperine can be enhanced by formulating them as solid lipid nanoparticles by using different preparation techniques and it can be effectively used for its diverse applications as mentioned earlier.

Keywords: Anti-Oxidant Activity; Bio Enhancing Activity; Anti-Tumor Activity; Anti-inflammatory Effect

×

References

  1. Shityakov S., et al. “Phytochemical and pharmacological attributes of piperine: A bioactive ingredient of black pepper”. European Journal of Medicinal Chemistry 176 (2019): 149-161.
  2. K Srinivasan. “Black Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects”. Critical Reviews in Food Science and Nutrition8 (2017): 735-748.
  3. Vasavirama K and Upender M. “Piperine: a valuable alkaloid from piper species”. International Journal of Pharmacy and Pharmaceutical Sciences 6 (2014): 34-38.
  4. Pruthi J. “Quality assurance in spices and spice products, modern methods of analysis”. New Delhi, India: Allied Publishers Ltd.
  5. Annu Khajuria., et al. “Permeability characteristics of piperine on oral absorption- An active alkaloid from peppers and a bioavailability enhancer”. 36 (1997): 46-50.
  6. Parthasarathy VA., et al. “Chemistry of spices”. London: CABI (2008).
  7. Darshan S and Doreswamy R. “Patented anti-inflammatory plant drug development from traditional medicine”. Phytotherapy Research 18 (2004): 343-357.
  8. Yang Y-C., et al. “A piperidine amide extracted from Piper longum L. fruit shows activity against Aedes aegypti mosquito larvae”. Journal of Agricultural and Food Chemistry 50 (2002): 3765-3767.
  9. Bai Y-F and Xu H. “Protective action of piperine against experimental gastric ulcer”. Acta Pharmaceutica Sinica B 21 (2000): 357-359.
  10. AM Mujumdar., et al. “Anti-inflammatory activity of piperine”. Japanese Journal of Medical Science and Biology 43 (1990): 95-100.
  11. Chonpathompikunlert P., et al. “Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease”. Food and Chemical Toxicology3 (2010): 798-802.
  12. Atal C., et al. “Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism”. Journal of Pharmacology and Experimental Therapeutics 232 (1985): 258-262.
  13. Raman G and Gaikar VG. “Microwave-assisted extraction of piperine from Piper nigrum”. Industrial and Engineering Chemistry Research 41 (2002b): 2521-2528.
  14. Mueller K and Hingst J. “The athlete’s guide to sports supplements”. Illinois, Ill.: Human Kinetics (2013).
  15. Vijayakumar R., et al. “Antioxidant efficacy of black pepper (Piper nigrumL.) and piperine in rats with high-fat-diet-induced oxidative stress”. Redox Report 9 (2004): 105-108.
  16. Kaul I and Kapil A. “Evaluation of liver protective potential of piperine: an active principle of black pepper”. Planta Medica 59 (1993): 413-417.
  17. Singh A and Rao A. “Evaluation of the modulatory influence of black pepper (Piper nigrum, L.) on the hepatic detoxication system”. Cancer Letter 72 (1993): 5-9.
  18. Sunila E and Kuttan G. “Immunomodulatory and antitumor activity of Piper longum Linn. and piperine”. Journal of Ethnopharmacology 90 (2004): 339-346.
  19. Doucette CD., et al. “Piperine, a dietary phytochemical, inhibits angiogenesis”. Journal of Nutritional Biochemistry 24 (2013): 231-239.
  20. Samykutty A., et al. “Piperine, a bioactive component of pepper spice exerts therapeutic effects on androgen-dependent and androgen-independent prostate cancer cells”. Planta Medica 8 (2013): e65889.
  21. Sosa S., et al. “Screening of the topical anti-inflammatory activity of some Central American plants”. Journal of Ethnopharmacology 81 (2002): 211-215.
  22. Tasleem F., et al. “Analgesic and anti-inflammatory activities of Piper nigrum L”. Asian Pacific Journal of Tropical Disease 7 (2014): 461-468.
  23. Bae G-S., et al. “Inhibition of lipopolysaccharide-induced inflammatory responses by piperine”. European Journal of Pharmacology 642 (2010): 154-162.
  24. Kim SH., et al. “Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model”. Journal of Pharmacy and Pharmacology 61 (2009): 353-359.
  25. Tatiraju VD., et al. “Natural bioenhancers: an overview”. Journal of Pharmacognosy and Phytochemistry 2 (2013): 55-60.
  26. Shailendra W., et al. “Bioavailability enhancement by piperine: A Review”. 4.36 (2014): 1-8.
  27. Mhaske DB., et al. “Role of Piperine as an Effective Bioenhancer in Drug Absorption”. Pharmaceutica Analytica Acta 7 (2018): 1-4.
  28. Kawada T and Sakabe S. “Some pungent principles of spices cause the adrenal medulla to secrete catecholamines in anesthetized rats”. Proceedings of the Society for Experimental Biology 188 (1988): 229-233.
  29. Tripathi P and Tripathi GS. “Thyrogenic response of Piper nigrum”. Fitoterapia 60 (1989): 539-542.
  30. F Namjoyan., et al. “Evaluation of drying process on the composition of black pepper ethanolic extract by HPLC with Diode array detector”. Jundishapur Journal of Natural Pharmaceutical Products 4 (2012): 163-167.
  31. R Subramanian., et al. “Double bypass Soxhlet apparatus for extraction of piperine from Piper nigrum”. Arabian Journal of Chemistry (2011).
  32. Guilia G., et al. “Optimisation of Naviglio assisted extraction followed by determination of piperine content in Piper longum extracts”. Natural Product Research 2 (2016): 214-217.
  33. S Dutta and P Bhattacharjee. “Enzyme assisted supercritical carbon dioxide extraction of black pepper oleoresin for enhanced yield of piperine rich extract”. Journal of Bioscience and Bioengineering (2014).
  34. Sachin S Rathod and Yirendra K Rathod. “Extraction of piperine from Piper longum using ultra sound”. Industrial Crops and Products 58 (2014): 259-264.
  35. Cao X., et al. “Ionic liquid based ultrasonic assisted extraction of piperine from white pepper”. Analytica Chimica Acta 640 (2009): 47-51.
  36. Tianzing Ren., et al. “Piperine loaded nanoparticles with enhanced dissolution and oral bioavailability for epilepsy control”. European Journal of Pharmaceutical Sciences (2019): 137.
  37. YeseminBudama-Kilinc. “Piperine nanoparticles for topical application: preparation, charecteristaion and In vitro and In silico evaluation”. Medicinal Chemistry and Drug Discovery 4 (2019): 11693-11700.
  38. MR Bhaleker., et al. “Formulation of piperine solid lipid nanoparticles for treatment of rheumatoid arthritis”. Drug Development and Industrial Pharmacy 6 (2017).
×

Citation

Citation: M Ravindra Babu., et al. “Emerging Diverse Medicinal Properties of Piperine: A Review".Acta Scientific Pharmacology 1.10 (2020): 30-35.




Metrics

Acceptance rate36%
Acceptance to publication20-30 days

Indexed In


News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US