K Mounika* and EAlekhya Goud
Department of Pharmacy Practice, Santhiram College of Pharmacy, Nandyal, Kurnool, Andhra Pradesh, India
*Corresponding Author: K Mounika, Department of Pharmacy Practice, Santhiram College of Pharmacy, Nandyal, Kurnool, Andhra Pradesh, India.
Received: June 27, 2020; Published: July 30, 2020
Bullous pemphigoid is a rare autoimmune disease which involves blisters formation betweenskin layers. It occurs due to production of autoantibodies against hemidesmosomal autoantigens BPAG1 and BPAG2. It mainly affects skin but rarely mouth, eye and genitals are also affected. The formation of blisters on the skin takes place due to malfunction in the immune system. The symptoms include severe itching, or erythematous skin with urticated and infiltrated plaques that are annular pattern. It is usually diagnosed by clinical, histopathological and immunological tests. The first line treatment is corticosteroids and the other treatment options are Immunosuppressant’s and certain antibiotics to decrease infection. A 64 years male patient admitted with C/O fluid filled lesions over hands and legs since 6 days. On cutaneous examination, patient has multiple tense dome shaped bullae of size ranging from 1 × 1cms to 2 × 3cms over flexor aspects of both upper limbs.Multiple wheals of size ranging from 1 × 1cms to 4 × 5cms present over dorsum of both hands, upper back and lateral aspects of both arms. On Histological examination, infiltration of eosinophils and lymphocytes were seen in upper dermis and bulla. Patient showed negative to Nikolsky sign and bulla spread sign. Patient was treated with Inj.Decadron OD, Tab.Taxim BD, Inj. Avil OD, Tab.Rantac BD, Tab.Fourts B OD, Fucibet cream BD, Tab. Bepozic OD.
Keywords: Bullous Pemphigoid;Autoimmune; Hemidesmosomal; Blisters; Nikolsky sign
Citation: K Mounika and EAlekhya Goud. “A Case Report On Potentially Fatal Condition-Bullous Pemphigoid". Acta Scientific Pharmacology 1.8 (2020): 24-27.
Copyright: © 2020 K Mounika and EAlekhya Goud. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.