Acta Scientific Pharmacology

Review Article Volume 1 Issue 7

CoVID-19: An Overview of the Characteristics, Diagnosis and Prevention of the Deadly Pandemic Disease

Mutthuraj D1, Gopenath TS2 and Kanthesh M Basalingappa1*

1Division of Molecular Biology, Faculty of Life Sciences, JSS AHER, SS Nagar, Mysuru, India
2Division of Biotechnology, Faculty of Life Sciences, JSS AHER, SS Nagar, Mysuru, India

*Corresponding Author: Kanthesh M Basalingappa, Assistant Professor, Division of Molecular Biology, Faculty of Life Sciences, JSS AHER, SS Nagar, Mysuru, India.

Received: May 06, 2020; Published: June 12, 2020

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Abstract

Coronavirus which causes severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) are highly infectious viral strains that belong to the group β - coronavirus family. Bats are believed to be the common origin-host of these viruses. The current pandemic caused by a similar coronavirus (SARS-CoVID-19) is also suspected to have originated from bats. However, there are different unresolved theories which are out of the scope of this review. With currently no vaccines or treatments available, except for the use of the drug Remdesivir, the world struggles to contain the virus. The only possible means to curb its spread is through proper detection, personal isolation and hygiene. Detection of this novel coronavirus is carried out using molecular biology techniques like- RT-PCR, ELISA and CRISPR based testing kits. CoVID-19 strain belongs to single-stranded positive-sense RNA viruses. Interestingly these viruses are capable of adapting and mutating to the new environment. The rapid transmission of the novel coronavirus around the world causing a severe mortality rate depends on this mutation or not is yet to be identified.

Keywords: CoVID-19; Novel Coronavirus; Pandemic; Diagnosis; Molecular Techniques

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References

  1. De Groot RJ., et al. “Family coronaviridae”. In King AM, Lefkowitz E, Adams MJ, Carstens EB, International Committee on Taxonomy of Viruses, International Union of Microbiological Societies. Virology Division, Oxford Elsevier (2011): 806-828.
  2. Cherry J., et al. “Feigin and Cherry’s Textbook of Pediatric Infectious Diseases”. Elsevier Health Sciences (2017): 6615.
  3. Almeida JD., et al. “Virology: coronavirus”. Nature 5168 (1968): 650.
  4. Estola T. “Coronaviruses, a new group of animal RNA viruses”. Avian Diseases2 (1970): 330-336.
  5. Mclntosh K. “Coronaviruses: A Comparative Review”. In: Arber W., et al. (editions) Current topics in microbiology and immunology/Ergebnisse der Mikrobiologie und Immunitatsforschung, Springer, Berlin, Heidelberg 63 (1974): 85-129.
  6. Kahn JS and McIntosh K. “History, and recent advances in coronavirus discovery”. The Pediatric Infectious Disease Journal 11 (2005): S223-S227.
  7. Hamre D and Procknow JJ. “A new virus isolated from the human respiratory tract”. Proceedings of the Society for Experimental Biology and Medicine1 (1966): 190-193.
  8. Wenjun L., et al. “Epidemiology, genetic recombination, and pathogenesis of coronaviruses, Cell Press”. Trends in Microbiology 6 (2016): P490-P502.
  9. Weiss SR and Navas-Martin S. “Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus”. Microbiology and Molecular Biology Reviews 4 (2005): 635-664.
  10. Durham PJ., et al. “Rotavirus and coronavirus associated diarrhea in domestic animals”. New Zealand Veterinary Journal3 (1979): 30-32.
  11. Wertheim JO., et al. “A case for the ancient origin of coronavirus”. Journal of Virology12 (2013): 7039-7045.
  12. David AJ., et al. “Coronavirus, Medical Microbiology”. University of Texas Medical Branch at Galveston. 4th (edition) chapter 60 (1996).
  13. Lanying D., et al. “Vaccines for the prevention against the threat of MERS-CoV”. Expert Review of Vaccines 9 (2017): 1123-1134.
  14. Muhammad AS., et al. “CoVID-19 infection: Origin, transmission, and characteristics of human coronaviruses”. Journal of Advanced Research 24 (2020): 91-98.
  15. Ben H., et al. “Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus”. PLoS Pathogens11 (2017): e1006698.
  16. Cui J., et al. “Origin and evolution of pathogenic coronaviruses”. Nature Reviews Microbiology 17 (2019): 181-192.
  17. Patrick CYW., et al. “Discovery of seven novels Mammalian and avian coronaviruses in the genus Delta-coronavirus supports bat coronaviruses as the gene sources of alpha-coronaviruses and beta-coronaviruses and avian Coronaviruses as the gene source of gamma-coronaviruses and delta coronaviruses”. Journal of Virology American Society of Microbiology (2012): 3995-4008.
  18. Susanna KPL., et al. “Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bat”. Proceedings of the National Academy of Sciences Of The United States Of America39 (2005): 14040-14045.
  19. Van der Hoek L., et al. “Identification of a new human coronavirus”. Nature Medicine 10 (2004): 368-373.
  20. Michael MC Lai and David Cavanagh. “The molecular biology of coronaviruses”. Advances in Virus Research 48 (1997): 01-100.
  21. Wei-Jie G., et al. “Clinical characteristics of coronavirus disease 2019 in china”. The New England Journal of Medicine 382 (2020): 1708-1720.
  22. Benjamin WN., et al. “Structural analysis of M protein in coronavirus assembly and morphology”. Journal of Structural Biology1 (2011): 11-22.
  23. Fehr AR and Perlman S. “Coronavirus: An overview of their replication and pathogenesis”. Methods in molecular biology Humana Press, New York 1282 (2015): 1-23.
  24. Du L., et al. “The spike protein of SARS-CoV–a target for vaccine and therapeutic development”. Nature Reviews Microbiology 7 (2009): 226-236.
  25. Rota PA. “Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome”. Science 300 (2003): 1394-1399.
  26. Zhiqi Song., et al. “From SARS to MERS, Thrusting Coronaviruses into the Spotlight”. Fang Li, Lanying Du (Editions.)”. MERS-CoV, Viruses MDPI 11.59 (2019): 22-49.
  27. Li Q., et al. “Early transmission dynamics of Wuhan, China, of novel coronavirus-infected Pneumonia”. The New England Journal Of Medicine 382 (2020): 1199-1207.
  28. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. The Lancet10223 (2020): 497-506.
  29. Hussin AR and Siddappa NB. “The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak”. Journal of Autoimmunity 109 (2020): 102433.
  30. Isaacs D., et al. “Epidemiology of coronavirus respiratory infections”. Disease in Childhood 58 (1983): 500-503.
  31. Graham S., et al. “Proteolytic activation of the SARS-coronavirus spike protein: cutting enzymes at the cutting edge of antiviral research”. Antiviral Research 3 (2013): 605-614.
  32. Dong Y., et al. “Epidemiology characteristics of 2143 pediatric patients with 2019 coronavirus disease in china”. Pediatrics (2020).
  33. Marco Cascella., et al. “Features, evaluation, and treatment coronavirus (CoVID-19), Stat Pearls Publishing”. Treasure Island (FL) (2020).
  34. World Health Organisation. Report of the WHO-China joint mission on coronavirus disease 2019 (COVID-19). World Health Organization Geneva (2020).
  35. Nidhi Subbaraman. “Coronavirus tests: researchers chase new diagnostics to fight the pandemic”. Nature (2020).
  36. Yi-Wei Tang., et al. “The Laboratory Diagnosis of COVID-19 Infection: Current Issues and Challenges”. Journal of Clinical Microbiology (2020).
  37. Booth CM., et al. “Clinical feature and short term outcomes of 144 patients with SARS in the greater Toronto area”. The Journal of the American Medical Association 21 (2003): 2801-2809.
  38. Subbarao K., et al. “Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice”. Journal of Virology 78 (2004): 3572-3577.
  39. Robert A., et al. “Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters”. Journal of Virology 79 (2005): 503-511.
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Citation

Citation: Kanthesh M Basalingappa., et al. “CoVID-19: An Overview of the Characteristics, Diagnosis and Prevention of the Deadly Pandemic Disease".Acta Scientific Pharmacology 1.7 (2020): 14-20.




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